AI Article Synopsis
- In dentistry, antimicrobials play a critical role in treating conditions like progressive periodontitis and odontogenic abscesses, necessitating the study of antibiotic susceptibility in bacteria causing these diseases.
- A study examined the effectiveness of several antibiotics (including clindamycin and metronidazole) against 164 isolates from patients with periodontitis and 192 strains from abscess pus, primarily focusing on gram-negative anaerobes.
- Results showed a high susceptibility to clindamycin and metronidazole among most tested bacteria, with a small percentage producing beta-lactamases, suggesting clindamycin as a suitable empirical treatment, except for specific pathogens like Actinobacillus actinomycetemcomitans.
Article Abstract
In dentistry antimicrobials are used in the treatment of progressive periodontitis and odontogenic abscesses, therefore the susceptibility to commonly used antibiotics of capnophilic and anaerobic species causing these diseases should be investigated. The activity of penicillin, amoxycillin, cefoxitin, clindamycin, doxycycline, metronidazole and ciprofloxacin was investigated. One hundred and sixty four isolates from subgingival plaque samples of 66 patients with progressive periodontitis and 192 bacterial strains from pus of 74 patients with odontogenic abscesses were included in this study. The majority of species tested were gram-negative anaerobes (Prevotella spp., Porphyromonas spp., Fusobacterium spp.), and were highly susceptible to clindamycin and metronidazole. Nearly 6% of the periodontal isolates and 22% of the bacteria obtained from pus samples produced beta-lactamases. With the exception of the periodontopathogenic species Actinobacillus actinomycetemcomitans and Eikenella corrodens, clindamycin seemed to be a useful antibiotic and could be recommended for empirical antimicrobial treatment.
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| http://dx.doi.org/10.1016/s0924-8579(99)00056-4 | DOI Listing |
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