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Genomics and Drug Discovery Strategies: The Role of Natural Compounds and Its Receptor in Alzheimer's Disease.
Cureus
January 2024
Genetics, Digianalix, Ranchi, IND.
Alzheimer's Disease (AD) is a special class of neurodegenerative diseases demarcated as a progressive disorder affecting especially older adults globally. The AD-infected brain shows declination in cognitive functions, memory loss, and other exhausting symptoms. In this study, we focused on using advanced bioinformatics and next-generation sequencing to explore essential clusters of genes from various diversified Alzheimer's, Parkinson and Frontotemporal Dementia diseased cases.
View Article and Find Full Text PDFThe impacts of menopausal hormone therapy on longer-term health consequences of ovarian hormone deficiency.
Climacteric
June 2023
Department of Obstetrics, Gynecology, and Women's Health, Sungkyunkwan University School of Medicine, Seoul, Korea.
This study on the longer-term health consequences of ovarian hormone deficiency (OHD) received the Henry Burger Prize in 2022. Osteoporosis, cardiovascular disease and dementia are major degenerative diseases that are also causally associated with OHD. Two randomized controlled trials (RCTs) revealed no significant difference in bone mineral density by adding alendronate to ongoing menopausal hormone therapy (MHT) or combining alendronate at MHT initiation.
View Article and Find Full Text PDFIdentification of the optimal cognitive drugs among Alzheimer's disease: a Bayesian meta-analytic review.
Clin Interv Aging
January 2019
Department of Child Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, School of Public Health, Soochow University, Suzhou, China,
Purpose: The increasing prevalence of Alzheimer's disease (AD) demands more effective drugs, which are still unclear. The aim of this study is to compare the effectiveness of six drugs, such as donepezil, rivastigmine, galantamine, memantine, huperzine-A, and tacrine, in senior AD patients and identify the most effective one to improve patients' cognitive function.
Methods: A system of search strategies was used to identify relevant studies including randomized controlled trials and clinical controlled trials evaluating the efficacy of six drugs in patients with AD.
Cholinergic medication for antipsychotic-induced tardive dyskinesia.
Cochrane Database Syst Rev
March 2018
Palliative Care (Home Hospital Services), Helsinki City Hospital, Helsinki, Finland.
Article Synopsis
- Tardive dyskinesia (TD) is a side effect of conventional antipsychotic medications, possibly linked to a lack of cholinergic activity, and cholinergic drugs have been explored as a treatment option for it.
- This study aimed to evaluate the effectiveness of various cholinergic drugs in treating antipsychotic-induced TD in individuals with schizophrenia or other chronic mental health issues.
- A systematic search identified 14 controlled trials conducted from 1976 to 2014, comparing the effects of cholinergic medications to placebo among patients with TD.
Rivastigmine for Alzheimer's disease.
Cochrane Database Syst Rev
April 2015
Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Windmill Road, Oxford, UK, OX3 7LD.
Background: Alzheimer's disease is the commonest cause of dementia affecting older people. One of the therapeutic strategies aimed at ameliorating the clinical manifestations of Alzheimer's disease is to enhance cholinergic neurotransmission in the brain by the use of cholinesterase inhibitors to delay the breakdown of acetylcholine released into synaptic clefts. Tacrine, the first of the cholinesterase inhibitors to undergo extensive trials for this purpose, was associated with significant adverse effects including hepatotoxicity.
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