Standardized panoramic radiographs were used to determine and compare the prevalences of focal osteosclerosis (including condensing osteitis) and apical periodontal pathoses in a sequential presenting sample of 600 European and 600 Cape Coloured dental outpatients. Most cases of focal osteosclerosis were found in edentulous zones or associated with carious or inadequately restored teeth; however, some were subjacent to apparently sound teeth. Focal osteosclerosis of definite dental origin was just as common in participants aged 25 years and older as in younger individuals. While focal osteosclerosis occurred predominantly in the mandible, apical periodontal pathoses were distributed more evenly between both jaws.
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http://dx.doi.org/10.1016/s0300-9785(78)80072-6 | DOI Listing |
BMC Mol Cell Biol
January 2025
Department of Stomatology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China.
Background: Inactivation or mutations of FAM20C causes human Raine Syndrome, which manifests as lethal osteosclerosis bone dysplasia or non-lethal hypophosphatemia rickets. However, it is only hypophosphatemia rickets that was reported in the mice with Fam20c deletion or mutations. To further investigate the local and global impacts of Fam20c mutation, we constructed a knock-in allele carrying Fam20c mutation (D446N) found in the non-lethal Raine Syndrome.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Staszica Street 11, 20-081, Poland.
Mastocytosis is a heterogeneous group of disorders, characterized by accumulation of clonal mast cells which can infiltrate several organs, most often spine (70%). The pathogenesis of mastocytosis bone disease is poorly understood. The main aim of the study was to investigate whether neoplastic mast cells may be the source of sclerostin and whether there is an association between sclerostin and selected bone remodeling markers with mastocytosis related bone disease.
View Article and Find Full Text PDFCureus
November 2024
Neuroradiology, Unidade Local de Saúde Vila Nova de Gaia | Espinho, Vila Nova de Gaia, PRT.
Erdheim-Chester disease (ECD) is a rare, multisystemic, non-Langerhans cell histiocytic neoplasm predominantly affecting middle-aged males in their fifth to seventh decades of life. It often presents with nonspecific symptoms, leading to a delay in its diagnosis. We report a case of an 85-year-old male with multisystemic manifestations, including retroperitoneal, skeletal, vascular, cardiac, orbital, and central nervous system (CNS) involvement.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disorder that commonly poses diagnostic challenges due to its atypical symptomatology. This observational study aimed to investigate the clinical features, laboratory test results, imaging features, and treatment strategies for pediatric patients with CRMO. We retrospectively analyzed 7 pediatric patients with CRMO treated at the Department of Pediatric Orthopedics, First Affiliated Hospital of Guangzhou University of Chinese Medicine between January 2018 and February 2022.
View Article and Find Full Text PDFJ Rheum Dis
October 2024
Rheumatology Department, Research Institute of Clinical and Experimental Lymрhology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
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