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Biochemical recurrence prediction after robot-assited radical prostatectomy (BCR-PRARP).
Heliyon
January 2025
Department of Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Objective: This study aimed to establish a robust predictive model for biochemical recurrence (BCR) in patients with prostate cancer who underwent robot-Assisted Radical Prostatectomy.
Material And Methods: A cohort of 1700 patients who underwent robot-assisted radical prostatectomy (RARP) for prostate cancer between August 2009 and December 2022 was included. BCR was defined as two consecutive PSA levels exceeding 0.
Leptin action on ARC-PVN neural circuit regulates ejaculation behavior by altering sympathetic neuroplasticity.
Andrology
January 2025
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Although some studies have revealed the close relationship between leptin and premature ejaculation in clinical practice, whether and how leptin participates in the regulation of ejaculatory behaviors are still unknown.
Objective: To explore the role of leptin on ejaculatory behaviors and its underlying mechanism.
Materials And Methods: Copulation behavior tests were performed after acute and chronic leptin administration at peripheral and central levels.
Semi-standardized evaluation of extraprostatic extension and seminal vesicle invasion with [F]PSMA-1007 PET/CT: a comparison to MRI using histopathology as reference.
EJNMMI Rep
January 2025
Department of Translational Medicine, Lund University, Lund, Sweden.
Background: Positron emission tomography/computed tomography (PET/CT) with prostate specific membrane antigen ligands (PSMA) is established for use in primary staging of prostate cancer to screen for metastases. It has also shown promise in local tumor staging, including detection of extraprostatic extension (EPE) and seminal vesicle invasion (SVI). Previous studies have shown high heterogeneity in methods and results.
View Article and Find Full Text PDFBlood-derived APLP1 extracellular vesicles are potential biomarkers for the early diagnosis of brain diseases.
Sci Adv
January 2025
Department of Biotechnology, College of Life Science, CHA University, Gyeonggi-do 13488, Republic of Korea.
Article Synopsis
- Early detection of neurodegenerative diseases relies on identifying brain-specific biomolecules in blood, and this study explores amyloid precursor-like protein 1 (APLP1) as a new biomarker found in extracellular vesicles (EVs).
- The research confirms that APLP1 EVs in human blood come from the brain, supported by distinct small RNA patterns and the expression of miRNA targets that are highly present in brain tissue.
- Validation using special mouse models (Thy-1 GFP M line) alongside data analysis highlights APLP1 EVs' potential as both diagnostic markers and key players in advancing neurodegenerative disease diagnosis.
Zinner Syndrome in a Young Male: A Case Report and Review of the Literature.
Cureus
December 2024
Radiodiagnosis, MNR Medical College and Hospital, Sangareddy, IND.
Zinner syndrome is an extremely uncommon congenital anomaly of the male urogenital tract. It is attributed to an embryological anomaly that arises in the distal segment of the mesonephric or Wolffian duct. It is the inadequate migration of the ureteric bud that contributes to the failure of differentiation of the metanephric blastema, which ultimately results in ipsilateral renal agenesis and atresia of the ejaculatory duct.
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