Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745526 | PMC |
| http://dx.doi.org/10.1136/thx.54.7.638 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluating a Public Health Assessment and Response Framework: SARS-CoV-2 Spread Under the Controlled Distancing Model of Rio Grande do Sul, Brazil.
Health Secur
January 2025
Ricardo Rohweder, MSc, is a PhD Student, Programa de Pós-Graduação em Genética e Biologia Molecular; Lavinia Schuler-Faccini, PhD, is a Professor, Department of Genética and Programa de Pós-Graduação em Genética e Biologia Molecular; and Gonçalo Ferraz, PhD, is a Professor, Programa de Pós-Graduação em Ecologia and Programa de Pós-Graduação em Genética e Biologia Molecular; all at the Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Lavinia Schuler-Faccini is also a Professor, Medical Genetics Service of Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
In early 2020, to halt the spread of SARS-CoV-2, the state government of Rio Grande do Sul in Brazil established a public health assessment and response framework known as a "controlled distancing model." Using this framework, the government divided the state into 21 regions and evaluated them against a composite index of disease transmission and health service capacity. Regions were assessed using a color-coded scale of flags that was updated on a weekly basis and used to guide the adoption of nonpharmaceutical interventions.
View Article and Find Full Text PDFInsights into Chronic Low Back Pain Etiology: Population-based genome-wide Association Study Identifies 18 Risk Loci.
Spine (Phila Pa 1976)
January 2025
Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
Study Design: Genome-wide association study (GWAS) meta-analysis with downstream analyses.
Objective: To explore the genetic architecture of chronic low back pain (cLBP) and identify underlying biological mechanisms that contribute to its development.
Summary Of Background Data: Chronic low back pain is prevalent and debilitating, with many cases having no identifiable biological cause.
Enhancing the accuracy of XPS calculations: Exploring hybrid basis set schemes for CVS-EOMIP-CCSD calculations.
J Chem Phys
January 2025
Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, USA.
Reliable computational methodologies and basis sets for modeling x-ray spectra are essential for extracting and interpreting electronic and structural information from experimental x-ray spectra. In particular, the trade-off between numerical accuracy and computational cost due to the size of the basis set is a major challenge, since molecular orbitals undergo extreme relaxation in the core-hole state. To gain clarity on the changes in electronic structure induced by the formation of a core-hole, the use of sufficiently flexible basis for expanding the orbitals, particularly for the core region, has been shown to be essential.
View Article and Find Full Text PDFSemirational Protein Engineering of a Decarboxylative Aldolase for Regiodivergent and Stereodivergent Synthesis of Cyclic Imino Acids.
Angew Chem Int Ed Engl
January 2025
Shanghai Institute of Materia Medica Chinese Academy of Sciences, Chemical Biology Research Center, 201203, Shanghai, CHINA.
Aldolases are powerful C-C bond-forming enzymes for asymmetric organic synthesis because of their supreme stereoselectivity, diverse electrophiles and nucleophiles, and promising scalability. Stereodivergent engineering of aldolases to tune the selectivity for the synthesis of stereoisomers of chiral molecules is highly desirable but has rarely been reported. This study documented the semirational engineering of the decarboxylative aldolase UstD with the focused rational iterative site-specific mutagenesis (FRISM) strategy to perform a C-C bond-forming reaction with dione electrophiles.
View Article and Find Full Text PDFEarly Evaluation of the Interaction and Gender Differences in Combination of Apatinib and Metoprolol Using Humanized CYP2D6 Model.
Chem Res Toxicol
January 2025
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, P.R. China.
Apatinib, a commonly used tyrosine kinase inhibitor in cancer treatment, can cause adverse reactions such as hypertension. Hypertension, in turn, can increase the risk of certain cancers. The coexistence of these diseases makes the use of combination drugs more common in clinical practice, but the potential interactions and regulatory mechanisms in these drug combinations are poorly understood.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!