Background: Nitric oxide (NO) plays an important role as an inflammatory mediator in the airways. Since chronic obstructive pulmonary disease (COPD) is characterised by airway inflammation, a study was undertaken to determine NO levels in the exhaled air of patients with COPD.
Methods: Two groups of patients with clinically stable COPD were studied, 10 current smokers and 10 ex-smokers. Two control groups of healthy subjects consisting of 10 current smokers and 20 non-smokers were also studied. Exhaled NO levels were measured by the collection bag technique and NO chemiluminescence analyser.
Results: Mean (SE) levels of exhaled NO in ex-smokers and current smokers with COPD (25.7 (3.0) ppb and 10.2 (1.4) ppb, respectively) were significantly higher than in non-smoker and current smoker control subjects (9.4 (0.8) ppb and 4.6 (0.4) ppb, respectively). In current smokers with COPD exhaled levels of NO were significantly lower than in ex-smokers. In this latter group of patients there was a significant negative correlation between smoking history (pack years) and levels of exhaled NO (r = -0.8, p = 0.002). A positive correlation was seen between forced expiratory volume in one second (FEV1) and levels of exhaled NO (r = 0.65, p = 0.001) in patients with COPD.
Conclusions: These data show that exhaled NO is increased in patients with stable COPD, both current and ex-smokers, compared with healthy control subjects.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1745512 | PMC |
| http://dx.doi.org/10.1136/thx.54.7.572 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Detection of Breath Nitric Oxide at Ppb Level Based on Multiperiodic Spectral Reconstruction Neural Network.
Anal Chem
January 2025
School of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China.
As breath nitric oxide (NO) is a biomarker of respiratory inflammation, reliable techniques for the online detection of ppb-level NO in exhaled breath are essential for the noninvasive diagnosis of respiratory inflammation. Here, we report a breath NO sensor based on the multiperiodic spectral reconstruction neural network. First, a spectral reconstruction method that transforms a spectrum from the wavelength domain to the intensity domain is proposed to remove noise and interference signals from the spectrum.
View Article and Find Full Text PDFA Study of Radium Content and Radon Exhalation Rates in Soil Samples from Abi-Adi Town, Ethiopia, Using LR-115 Type-II.
Health Phys
January 2025
Ayder Comprehensive Specialized Hospital, Mekelle University, Tigray, Ethiopia.
In the present study, we are presenting the results of radium content, radon concentration, and radon exhalation rates (both mass and area) for 32 soil samples collected from different locations of Abi-Adi Town, Ethiopia, by using the sealed can technique containing a LR-115 Type-II plastic detector. The values of radium content from soil samples were found to vary from 35.26 Bq kg-1 to 101.
View Article and Find Full Text PDFEffectiveness of a Dentist-based Anti-Smoking Intervention Among Malaysian Adolescents: A Randomized Controlled Field Trial.
Asian Pac J Cancer Prev
January 2025
Department of Community Oral Health and Clinical Prevention, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.
Background: The KOTAK program is a national public health initiative in Malaysian primary and secondary schools aimed at reducing youth smoking through school dental services. This study evaluated its effectiveness in Seremban, Negeri Sembilan, Malaysia.
Objectives: 1) To determine the percentage of schoolchildren who quit smoking through the KOTAK program; 2) To identify factors associated with quitting smoking in the program.
A Non-invasive Lung Disease Study of Exhaled Breath Nitric Oxide Based on Ultraviolet Differential Absorption Spectroscopy Techniques.
J Biophotonics
January 2025
Clinical Research Center for Respiratory Disease (Tumor) in Anhui Province, Bengbu, Anhui Province, China.
In this study, a non-invasive device based on ultraviolet differential absorption spectroscopy (UV-DOAS) technology for detecting fractional exhaled nitric oxide (FeNO)was developed and clinically validated in patients with various lung diseases. The diagnostic potential of FeNO was explored by analysing subgroups of patients with lung cancer, nodules, and other disease. The results showed that FeNO concentrations were significantly higher in patients with malignant tumours than in healthy controls (p < 0.
View Article and Find Full Text PDFComparing the Effects of Square, 4-7-8, and 6 Breaths-per-Minute Breathing Conditions on Heart Rate Variability, CO Levels, and Mood.
Appl Psychophysiol Biofeedback
January 2025
Department of Psychology, Brigham Young University, Salt Lake City, UT, USA.
Square and 4-7-8 breathing are popularly promoted by psychotherapists but have little empirical support. We hypothesized that breathing at 6 breaths per minute (bpm) would improve HRV, reduce blood pressure, and improve mood more than either square or 4-7-8 breathing. We also hypothesized square and 4-7-8 breathing would increase end-tidal CO (PETCO).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!