AI Article Synopsis
- The study assessed the impact of various factors like age, tumor size, and lymph node metastasis on the prognosis of stage IB-IIA cervical cancer patients.
- A total of 100 patients who underwent radical hysterectomy followed by radiotherapy were analyzed, revealing 5-year survival rates of 83.6% for overall survival and 82.8% for disease-free survival.
- Key findings identified pelvic lymph node metastasis, interval between radiotherapy and surgery, and overall radiotherapy time as significant predictors of patient outcomes and treatment success.
Article Abstract
Purpose: This study investigated the prognostic significance of age, stage, tumor size, pelvic lymph node metastasis (PLM), surgical margin invasion, overall radiotherapy time (ORT), and interval between radiotherapy and surgery (IRS) in stage IB-IIA cervical carcinoma.
Method And Materials: 100 patients treated with radical hysterectomy and postoperative radiotherapy were evaluated retrospectively.
Results: The 5-yr overall survival (OS), disease-free survival (DFS), and pelvic control rate (PC) were 83.6%, 82.8%, and 91.8%, respectively. PLM (p=0.008), IRS (p=0.01), ORT (p=0.007), and tumor size (p=0.028) were found to be significant on PC. PLM (p=0.04), ORT (p=0.04), and IRS (p=0.001) were significant on OS. PLM was significant (p=0.04) and IRS was marginally significant (p=0.06) on DFS. After multivariate analysis, PLM was significant on OS, DFS and PC. Recurrences were seen in 14 patients.
Conclusion: According to this study PLM, IRS, and ORT are the most important prognostic factors. Recurrences outside the radiation volume leads to treatment failure.
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