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Biomarkers of chronic spontaneous urticaria and their clinical implications.
Expert Rev Clin Immunol
March 2021
Medicina Interna, Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Università degli Studi di Milano, Milano, Italy.
: Chronic spontaneous urticaria (CSU) is a frequent disorder in which activation of effector cells and histamine release can be induced via several distinct pathogenetic mechanisms. Much work has been carried out to identify biomarkers useful for classifying CSU patients, and to predict their response to currently available treatments.: The recent literature dealing with CSU biomarkers was screened in PubMed and Google Scholar using 'chronic spontaneous urticaria', 'biomarker', 'diagnosis', 'therapy' and 'treatment response' as key words.
View Article and Find Full Text PDFAutoallergy: a pathogenetic factor in atopic dermatitis?
J Allergy Clin Immunol
March 2000
Institute of General and Experimental Pathology, Division of Environmental Dermatology and Allergology GSF/Technical University Munich, Germany.
Long before the discovery of IgE it was reported that human dander extract can elicit immediate-type skin reactions in patients with severe atopy and that this skin sensitivity can be passively transferred with serum. Several recent findings have rekindled the interest in this phenomenon and led to the concept that IgE autoreactivity may play a pathogenetic role in severe and chronic forms of atopy. The elucidation of the nature of several environmental allergens has revealed striking structural and immunologic similarities with human proteins.
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Curr Probl Dermatol
September 1999
Department of General and Experimental Pathology, Vienna General Hospital, University of Vienna, Austria.
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