Adrenalin is the drug for anaphylactic shock. The product is usable directly by the patient in the form of an auto-injectable kit, by the physician who treats by the sublingual or subcutaneous routes, in a resuscitation unit extra and inter-hospital by the intra-veinous route with cardiac monitoring. Precaution have to be observed (in angina especially), but it is without formal contra-indications. The beta 2 adrenergics are non-specific bronchodilators. Two categories are available: short action molecules, crisis drugs, prolonged activity molecules (greater than 12 hours). Several routes of administration are useable: spray or powder (inhalation) sub-cutaneous, taking by mouth.
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Endocrine
January 2025
Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
The word "cancer" evokes myriad emotions, ranging from fear and despair to hope and determination. Cancer is aptly defined as a complex and multifaceted group of diseases that has unapologetically led to the loss of countless lives and affected innumerable families across the globe. The battle with cancer is not only a physical battle, but also an emotional, as well as a psychological skirmish for patients and for their loved ones.
View Article and Find Full Text PDFPlatelets
December 2025
Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA.
Platelet-like particles (PLPs), derived from megakaryocytic cell lines MEG-01 and K-562, are widely used as a surrogate to study platelet formation and function. We demonstrate by RNA-Seq that PLPs are transcriptionally distinct from platelets. Expression of key genes in signaling pathways promoting platelet activation/aggregation, such as the PI3K/AKT, protein kinase A, phospholipase C, and α-adrenergic and GP6 receptor pathways, was missing or under-expressed in PLPs.
View Article and Find Full Text PDFBiomolecules
November 2024
Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.
Chronic stress is associated with a higher risk for carcinogenesis as well as age-related diseases and immune dysfunction. There is evidence showing that psychological stress can contribute to premature immunosenescence. Therefore, the question arose whether chronic exposure to catecholamine could drive immune cells into senescence.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
February 2025
Laboratory for Applied Human Physiology, Graduate School of Human Development and Environment, Kobe University, Kobe, Japan.
The assessment of adrenergic modulation of sweating as assessed via pharmacologic administration of α- and β-adrenergic receptor blockers during exercise has yielded mixed findings. However, the underlying mechanisms for this disparity remain unresolved. We investigated the effects of separate and combined blockade of α- and β-adrenergic receptors on forearm sweating induced by a 30-min moderate-intensity exercise bout ( = 17, ) and the administration of adrenergic agonists epinephrine and norepinephrine ( = 16, ) in the heat.
View Article and Find Full Text PDFJ Pediatr Endocrinol Metab
December 2024
Division of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Objectives: Limited data are available on the hormonal response of children to venepuncture or intravenous cannulation (IVC). Catecholamines [epinephrine (E) and norepinephrine (NE)] have been traditionally recognized as stress hormones. Copeptin, the carboxyl-terminus of the arginine vasopressin (AVP) precursor peptide, is also a known marker for stressful stimuli, including myocardial infarction, critical illness, and sepsis.
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