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Changes in and Potential Mechanisms of Circulating IgA+CD27-Class-Switched Memory B Cells in Patients With Allergic Rhinitis.
J Asthma Allergy
January 2025
Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Background: The role of memory B cells and their subgroups in allergic rhinitis (AR) and allergen immunotherapy (AIT) remains unclear. This study aimed to investigate the characteristics of memory B cells in the circulation of patients with AR and those undergoing AIT, as well as their clinical significance.
Methods: This study involved a cohort comprising 32 healthy control subjects, 39 individuals diagnosed with AR, and 31 AR patients who had received AIT for over one year.
Mixed Pulmonary Infection, Asthma, and Nephrotic Syndrome in a Patient Diagnosed with Selective IgA Deficiency: A Case Report.
J Inflamm Res
January 2025
Zhejiang Provincial Hospital of Integrated Traditional Chinese and Western Medicine, Zhejiang, 310003, People's Republic of China.
Patients with selective IgA deficiency could have various clinical presentations ranging from asymptomatic to severe respiratory or gastrointestinal tract infection, as well as autoimmune disease and allergic reactions. Selective IgA deficiency is relatively common in Caucasians, but it is rare in the Asian population, meaning it could be easily missed in the clinic. In this study, we report a 26-year-old man with a history of asthma and nephrotic syndrome.
View Article and Find Full Text PDFRegistries in allergy: Structure, target groups, and key findings of allergy-focused registries in Germany.
Allergol Select
December 2024
Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
In allergology, clinical registries fill knowledge gaps of epidemiology, mechanisms of allergic diseases, and real-world treatment outcomes. Considering the continuous rise of allergic diseases worldwide, registries become increasingly important for the optimization and harmonization of patient care. In the current review, we present four ongoing allergy-focused registries initiated in Germany.
View Article and Find Full Text PDFTherapeutic effects and mechanisms of berberine on enteritis caused by in poultry.
Front Microbiol
November 2024
Xinjiang Key Laboratory of Herbivore Drug Research and Creation, College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, Xinjiang, China.
Article Synopsis
- The study explored the effects of berberine (BBR) on enteritis in broiler chickens by examining immune responses and organ health in 21- to 35-day-old chicks.
- Results showed that BBR treatment increased serum immunoglobulin levels, antioxidant capacity, and improved gut microbiota by promoting beneficial bacteria while reducing harmful ones.
- Transcriptome analysis indicated that BBR influences immune-related gene expression, particularly affecting pathways linked to T and B cell signaling, demonstrating its potential as a therapeutic agent against intestinal inflammation.
Is gastrointestinal epithelial barrier dysfunction the only responsible for sensitization to food allergens?
Eur Ann Allergy Clin Immunol
November 2024
Clinical and Laboratory Molecular Allergy Unit, Fondazione Luigi Maria Monti, IDI-IRCCS, Rome, Italy.
Article Synopsis
- Epithelial barriers are vital for protecting against pathogens and allergens, and when environmental factors compromise them, conditions like asthma and food allergies can arise.
- While the dysfunction of skin and respiratory barriers in allergies is well-established, the gut epithelium's role in food allergies is less clear, as it usually maintains integrity and fosters immune tolerance through specific immune mechanisms.
- Research indicates that certain food allergies, such as those to cow's milk and hen's egg, often resolve with age, and studies like the LEAP trial suggest that early allergen exposure can help prevent allergies, showcasing the complex nature of allergen sensitization beyond just food intake.
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