The method of prophylaxis and treatment of an early complications of surgical treatment of the mammarial gland tumors using native biological fibrinous glue "Bioadhesive" was proposed. The preparation application had permitted to reduce the operative wound healing duration, to reduce a wound exudate quantity, the duration and intensity of lymphorrhea and the seroma rise frequency, and to improve significantly an operative intervention cosmetic result.
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Angew Chem Int Ed Engl
January 2025
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Bioceramics Division, Biomedical Technology Wing, 695011, Thiruvananthapuram, INDIA.
A collagen-inspired helical protein-mimic has been synthesized via topochemical polymerization of a designed tripeptide monomer. In the monomer crystal, molecules arrange in a head-to-tail manner, forming supramolecular helices. The azide and alkyne of adjacent molecules in the supramolecular helix are proximally preorganized in a ready-to-react arrangement.
View Article and Find Full Text PDFBiomaterials
December 2024
Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou, 310009, China; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, Hangzhou, 310009, China. Electronic address:
Tissue adhesives have attracted significant interest in the field of hemostasis. However, challenges including weak tissue adhesion, inadequate biocompatibility, and instability limit their clinical applications. Here, we have developed a gelatin-DOPA-knob/fibrinogen hydrogel inspired by the fibrin polymerization and mussel adhesion, resulting in a biocompatible bioadhesive with outstanding adhesion performance and great storage stability.
View Article and Find Full Text PDFBackground And Aims: An effective surgical adhesive must possess strength, biodegradability, flexibility, non-toxicity, and the ability to accommodate to tissue movement. However, existing adhesives in the market lack some of these crucial properties. Both synthetic cyanoacrylate and natural fibrin glue have been explored for sutureless oral surgery, but they come with specific limitations.
View Article and Find Full Text PDFAdv Healthc Mater
November 2024
Department of Orthopaedic, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai, 200336, China.
Discectomy serves as the primary therapeutic approach for lumbar disc herniation, but the annular fibrosus defects after discectomy may lead to recurrence of disc herniation. Despite recent advances in bioinspired adhesives to seal the AF defect, the growing popularity of endoscopic discectomy has put forward high requirements for the tissue bioadhesives with rapid injectability, easy operation, and robust tissue adhesion in underwater environments. Herein, a rapidly in situ forming injectable tetra-PEG bioadhesive (ISG) comprising of FDA-approved tetra-armed poly (ethylene glycol) amine (tetra-PEG-NH) and tetra-armed poly (ethylene glycol) succinimidyl glutarate (tetra-PEG-SG) for the sutureless closure of AF defects, is reported.
View Article and Find Full Text PDFSci Rep
October 2024
Université Paris Cité, CNRS, Institut Jacques Monod, 75005, Paris, France.
Drosophila glue, a bioadhesive produced by fly larvae to attach themselves to a substrate for several days, has recently gained attention for its peculiar adhesive and mechanical properties. Although Drosophila glue production was described more than 50 years ago, a general survey of the adhesive and mechanical properties of this proteinaceous gel across Drosophila species is lacking. To measure adhesion, we present here a protocol that is robust to variations in protocol parameters, pupal age and calculation methods.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!