The process of luteinization, during which follicular granulosa cells are transformed into luteal cells, is accompanied by dramatic changes in the responses of luteal cells to luteinizing hormone (LH) and cAMP. The goal of this review is to summarize the findings of recent studies in monkeys, which have shown that the expression of the cAMP-dependent nuclear transcription factor CREB (cAMP-response element-binding protein) ceases upon luteinization, and also to suggest possible consequences of its loss on corpus luteum function and lifespan.
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