AI Article Synopsis
- New aminosterols were synthesized and tested for their ability to inhibit cell growth.
- The study focused on a human non small-cell lung cancer cell line (NSCLC-N6) and evaluated how these compounds affected the cell cycle.
- Results showed that compounds I-III caused cell blockage in the G1 phase, leading to fewer cells in the S and G2M phases and an increase in cellular debris from G1 phase cells.
Article Abstract
Various new aminosterols were synthesized. The antiproliferative activity of these compounds (I-IV) was studied in vitro on a continuous human non small-cell bronchopulmonary carcinoma line (NSCLC-N6) at the cell cycle level. The histograms indicate cell blockage in Phase Gl (compound I-III) associated with a reduction in the number of cells phases S and G2M and appearance of cellular debris derived from cells in Phase G1.
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