Subclinical copper accumulation in llamas.

Can Vet J

Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.

Published: June 1999

A 9-year-old, intact male llama with mild ataxia and generalized malaise of 1 month's duration was euthanized following clinical evaluation. Excessive liver copper concentrations were found in the llama and also in clinically normal herdmates. This case documents multiple animals with increased hepatic stores from standard diets and mineral supplements.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539711PMC

Publication Analysis

Top Keywords

subclinical copper
4
copper accumulation
4
accumulation llamas
4
llamas 9-year-old
4
9-year-old intact
4
intact male
4
male llama
4
llama mild
4
mild ataxia
4
ataxia generalized
4

Similar Publications

Brain morphometry in hepatic Wilson disease patients.

J Inherit Metab Dis

January 2025

Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.

Wilson disease (WD) primarily presents with hepatic and neurological symptoms. While hepatic symptoms typically precede the neurological manifestations, copper accumulates in the brain already in this patient group and leads to subclinical brain MRI abnormalities including T2 hyperintensities and atrophy. This study aimed to assess brain morphological changes in mild hepatic WD.

View Article and Find Full Text PDF

Alterations to the gut microbiome and exposure to metals during pregnancy have been suggested to impact inflammatory bowel disease. Nonetheless, how prenatal exposure to metals eventually results in long-term effects on the gut microbiome, leading to subclinical intestinal inflammation, particularly during late childhood, has not been studied. It is also unknown whether such an interactive effect drives a specific subgroup of children toward elevated susceptibility to intestinal inflammation.

View Article and Find Full Text PDF
Article Synopsis
  • A study investigated the link between urinary metal levels (both nonessential and essential) and the progression of coronary artery calcium (CAC), a marker for cardiovascular disease, in participants from the Multi-Ethnic Study of Atherosclerosis (MESA).
  • Results showed that higher levels of metals like cadmium, tungsten, uranium, and cobalt were associated with significantly increased CAC levels over 10 years, indicating a potential risk factor for cardiovascular disease.
  • The findings suggest that exposure to certain metals has a comparable impact on coronary calcification as traditional cardiovascular risk factors, emphasizing the need for further research into environmental influences on heart health.
View Article and Find Full Text PDF

Oxidative stress and renal status of farmers exposed to pesticides in Seville (Spain).

Sci Total Environ

November 2024

Department of Nutrition and Bromatology, Toxicology, and Legal Medicine, Faculty of Pharmacy, University of Sevilla, Sevilla, Spain.

The aim was to determine whether indirect exposure to pesticides, specifically a copper-based fungicide, induces alterations in oxidative stress and subclinical and early kidney biomarkers in male farmers tasked with olives harvesting. Furthermore, we tested whether sex influences the susceptibility to pesticide-induced renal damage by comparing the results of this study with those obtained previously. The study focused on olive farmers (n = 41) indirectly exposed to copper-based fungicides in Estepa (Sevilla, Spain), comparing them with a control group (n = 32).

View Article and Find Full Text PDF

Objective: In Wilson's disease (WD), copper accumulation in the organs and/or damage caused by oxygen free radicals occurs due to disturbances in copper excretion. In our study, we aimed to evaluate cardiac involvement with advanced echocardiographic modalities (tissue Doppler echocardiography, strain and strain-rate echocardiography).

Methods: Twenty WD patients and 20 healthy children from the Pediatric Gastroenterology Department of Diyarbakır Children's Hospital were included in the study between 2022 and 2023.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!