In experiment with mice and rats radioprotective properties of direct alpha-adrenomimetic drugs: indraline, mesaton (phenylephrine) and naphthyzine (naphazoline) have been investigated by local early and late radiation injuries. The drugs were S. C. and C. administrated at the site of the thigh of the hind of the animal at intervals of 5-8 min locally was irradiated with gamma-60Co-rays in the doses of 26.3-53.7 Gy at a rate of the dose of 1.31-1.54 Gy/min. When S. C. injected the topical effect of the adrenomimetics was higher than the systemic one. In experiment with mice radioprotective efficiency of topical indraline (S. C. 50 and 100 mg/kg) in term of DRF was equal to 1.34 and 1.67 for radiation burn of the skin, 1.56 and 1.91 for 3rd month radiation contracture of the hind and 1.10 and 1.50 for partial amputation of the one. In the same condition the effect of topical mesaton (S. C. 1, 2.5, 5 mg/kg) in term of DRF was accordingly equal to 1.29, 1.49 and 1.62 for early radiation injury, 1.08, 1.20 and 1.46 for 3th month radiation contracture of the hind and 1.0, 1.14, 1.33 for partial amputation of the one; the effect of topical naphthyzine (5 mg/kg) in the term of DRF was 1.36 for early radiation injury. In experiment with rats radioprotective property of systemic indraline (I. M. 100 mg/kg) in the term of DRF was equal to 1.39 for radiation burn of the skin, 1.39 for 6th month radiation contracture of the hind, 1.41 for partial amputation of the one. When C. administrated the effect of topical indraline (5% solution in 50% DMSO or ethyl alcohol solution) in term of DRF was accordingly equal to 1.17 and 1.18 for radiation burn ot the skin, 1.50 and 1.35 for radiation contracture of the hind, 1.41 and 1.28 for amputation of the one. When S. C. administrated the effect of topical and systemic mesaton (2.5 mg/kg) in term of DRF was accordingly equal to 1.30 and 1.04 for radiation burn ot the skin. 1.25 and 1.0 for radiation contracture of the hind, 1.30 and 1.0 for amputation of the one.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Optimising episodic encoding within segmented virtual contexts.
Conscious Cogn
January 2025
School of Psychology and Neuroscience, University of St. Andrews. KY16 9JP, United Kingdom.
The encoding of episodic memories depends on segmentation; memory performance improves when segmentation is available and performance is impaired when segmentation is absent. Indeed, for episodic memories to be created, the encoding of information into long-term memory requires the experience of event boundaries (i.e.
View Article and Find Full Text PDFAn examination of the dose rate effect in mice assuming that the carcinogenic effect of radiation is life shortening resulting from a tissue reaction.
Int J Radiat Biol
January 2025
Department of Radiation Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
Purpose: Radiation exposures do not seem to increase the proportion of mice dying from tumors, but rather cause a shift in the appearance of spontaneous cancers, allowing them to appear earlier, and hence produce a life shortening effect. Then, it was possible to estimate the effect of the dose rate on the carcinogenic effects of radiation using life shortening effects as a measure.
Conclusion: The dose response for the induction of life shortening was linear under acute exposure conditions, which indicates that the response under chronic exposure conditions is also likely to be linear, and hence the dose rate factor (DRF) would be constant throughout the dose.
Risk for Flexor Pollicis Longus Rupture after Volar Lock Plating for Distal Radius Fracture Lasts Over a Decade.
Arch Bone Jt Surg
January 2024
Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore.
Article Synopsis
- The study investigates the long-term risk of attritional flexor tendon ruptures in patients who underwent volar locking plate fixation for distal radius fractures (DRFs) from 2016 to 2021.
- Five patients with flexor pollicis longus (FPL) ruptures were identified, with a median age of 48 years and a median time from VLP fixation to rupture of 7 years.
- The research concludes that older generation VLP fixations (Soong grade 2) carry a significant risk for FPL ruptures, which can be successfully treated with palmaris longus tendon grafts, achieving satisfactory functional outcomes.
A comparative study on the efficacy of laparoscopic ureteroureterostomy versus single ureteral bladder reimplantation in treating pediatric complete renal duplication.
Pediatr Surg Int
November 2024
Department of Pediatric Surgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, China.
Objective: To explore the therapeutic value of laparoscopic ureteroureterostomy compared to single ureteral bladder reimplantation in the treatment of pediatric complete renal duplication.
Methods: This retrospective study included 80 pediatric patients with complete renal duplication who underwent surgical treatment at the First Affiliated Hospital of Zhengzhou University from January 2015 to December 2022. Patients were divided into two groups based on the surgical approach: the laparoscopic ureteroureterostomy group (LUU group, n = 45) and the single ureteral bladder reimplantation group (UR group, n = 35).
The NITRATE-OCT study-inorganic nitrate reduces in-stent restenosis in patients with stable coronary artery disease: a double-blind, randomised controlled trial.
EClinicalMedicine
November 2024
Barts and the London Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Background: Coronary angioplasty and stent insertion is a first line treatment for patients with coronary artery disease, however it is complicated in the long-term by in-stent restenosis (ISR) in a proportion of patients with an associated morbidity. Despite this, currently there are no effective treatments available for the prevention of ISR. Repeat percutaneous revascularisation carries increased risks of major adverse cardiovascular events and a higher incidence of stent failure.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!