AI Article Synopsis
- The study assessed liver tissue changes in chronic hepatitis B patients receiving 52 weeks of lamivudine therapy.
- Ninety-five percent of patients showed a significant reduction in liver necroinflammation, and 35% improved in fibrosis.
- The positive results were consistent regardless of the patient's e-antigen status.
Article Abstract
Background/aims: The aim of this study was to examine the histological changes in liver biopsies induced by 52 weeks of lamivudine therapy in patients with e-antigen positive and e-antigen negative chronic hepatitis B infection.
Methods: Twenty patients were enrolled into this open-label study. All patients had a liver biopsy within the 4 weeks before starting lamivudine therapy. Lamivudine was given orally at a dose of 100 mg OD for 52 weeks. A second liver biopsy was taken for comparison at the end of week 52. Blinded biopsies were evaluated by a histopathologist and scored according to Knodell's histology activity index (HAI).
Results: Ninety-five percent (19/20) patients had a reduction of their hepatic necroinflammatory HAI score (components 1 through 3) by > or =2 points at the end of 52 weeks of lamivudine therapy compared to their pretreatment values. Not only were improvements in necroinflammatory activity observed, but 7/20 (35%) of patients had improvement in fibrosis. This histologic improvement was independent of the presence or absence of e-antigen.
Conclusions: Significant improvements in liver histology can be obtained in the majority of patients when they are treated with lamivudine for 1 year.
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| http://dx.doi.org/10.1016/s0168-8278(99)80123-8 | DOI Listing |
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