The fetal recurrent loss (P.F.R.), it is a clinical disturbance associated with multiple factors, that it are in a frustrating situation so much for the couples like for the doctor. The objective was to evaluate 39 couples with P.F.R. in order to establish the responsibility of each factor and proceed to treatment I specify, considering as success the get a pregnancy with viable product. The protocol included clinical history, histerosalpingography, ultrasound, analysis cromosomal, antibodies for TORCH and antiphospholipids, test endocrine specifies, genitals cultivation and biopsy of endometrial. 23% it of the fetal losses is due to only factor; 64.2% it is due to multiple factors and 12.8% they don't have apparent factor. The infectious factors, endocrine, anatomical and autoimmunity was the more constants. Pregnancy with viable product in the 82% was achieved of the cases. We concluded that the P.F.R. it is a problem that is due to multiple factors and that it require a diagnosis-therapeutic integral focus.
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JAMA Cardiol
January 2025
Ifakara Health Institute, Ifakara Branch, Ifakara, United Republic of Tanzania.
Importance: Hypertension is the primary cardiovascular risk factor in Africa. Recently revised World Health Organization guidelines recommend starting antihypertensive dual therapy; clinical efficacy and tolerability of low-dose triple combination remain unclear.
Objectives: To compare the effect of 3 treatment strategies on blood pressure control among persons with untreated hypertension in Africa.
Rheumatology (Oxford)
January 2025
Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain.
Objectives: COVID-19 and systemic sclerosis (SSc) share multiple similarities in their clinical manifestations, alterations in immune response, and therapeutic options. These resemblances have also been identified in other immune-mediated inflammatory diseases where a common genetic component has been found. Thus, we decided to evaluate for the first time this shared genetic architecture with SSc.
View Article and Find Full Text PDFQual Life Res
January 2025
Occupational Medicine Department, University Hospital Sahloul, Sousse, Tunisia.
Background: Since the COVID-19 pandemic, health care workers (HCWs) faced an enormous physical and mental burden, sometimes altering their quality of life due mainly to persistent challenges stemming from their frontline position.
Aims: Todetermine the prevalence of post-COVID-19 syndrome, and its impact on the Health-Related Quality of Life (HRQoL) among HCWs.
Methods: This is an exhaustive cross-sectional study with analytical scope, conducted among all HCWs of the University Hospital Sahloul of Sousse, Tunisia, who have contracted COVID-19 between September 2020 and 30 March 2021 (N=529 cases).
Target Oncol
January 2025
Berenson Cancer Center, West Hollywood, CA, USA.
Multiple myeloma (MM) is a bone-marrow-based cancer of plasma cells. Over the last 2 decades, marked treatment advances have led to improvements in the overall survival (OS) of patients with this disease. Key developments include the use of chemotherapy, immunomodulatory drugs, proteasome inhibitors, and monoclonal antibodies.
View Article and Find Full Text PDFPsychiatr Q
January 2025
Department of Psychological Counseling, Abant Izzet Baysal University, Bolu, Türkiye.
Natural disasters such as earthquakes leave deep psychological effects on individuals that can lead to posttraumatic stress disorder, and understanding these effects is vital to support psychological recovery processes after trauma. In this context, the aim of this study was to examine the mediating role of emotion regulation difficulties, religious coping, positive reappraisal and seeking social support in the relationship between posttraumatic cognitive attributions and posttraumatic stress disorder in 2023 Kahramanmaraş Pazarcık, Elbistan and Hatay Yayladağı earthquake survivors (N = 408). The findings from the multiple mediation analysis showed the indirect effect of posttraumatic cognitive attribution on PTSD through difficulties in emotion regulation, religious coping, positive reappraisal, and seeking social support.
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