The anxiolytic effect of Eurycoma longifolia Jack in mice was examined. Fractions of E. longifolia Jack extract produced a significant increase in the number of squares crossed (controls= 118.2 +/- 10.2 squares), but significantly decreased both the immobility (controls = 39.4+/- 4.0 sec) and fecal pellets (controls= 12.3 +/-2.1 fecal pellets) when compared with control mice in the open-field test; they significantly increased the number of entries (controls=6.7+/-0.5 entries) and time spent (controls=42.9+/-0.1 sec) in the open arms, but decreased both the number of entries (controls= 13.2+/-0.7 entries) and time spent (controls= 193.4+/-0.7 sec) when compared with the control mice in the closed arms of the elevated plus-maze test. Furthermore, fractions of E. longifolia Jack extract decreased the fighting episodes significantly (controls= 18.0+/-0.4 fighting episodes) when compared with control mice. In addition, these results were found to be consistent with anxiolytic effect produced by diazepam. Hence, this study supports the medicinal use of this plant for anxiety therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1254/jjp.79.497 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Literature research and discussion on properties of a new oversea-introduced traditional Chinese medicine Malaysian ginseng(Tongkat Ali)].
Zhongguo Zhong Yao Za Zhi
September 2024
Amway (Shanghai) Technology Development Co., Ltd. Shanghai 201203, China.
Tongkat Ali(Eurycoma longifolia Jack.) is a medicinal plant of Simaroubaceae in Southeast Asia, with centuries of medicinal history. Rich clinical and pharmacological research results have been attained for this plant, which demonstrates diverse and definite effects and high safety, showcasing advantages and broad market prospects to be introduced as a new medicinal plant.
View Article and Find Full Text PDF<b>Background and Objective:</b> <i>Eurycoma longifolia</i> roots hold traditional medicinal value, but scientific evaluation of their bioactivity and safety is lacking. This study investigated the antioxidant and anticancer potential of <i>E. longifolia</i> extracts and assessed cytotoxicity.
View Article and Find Full Text PDFMetabolome classification of Tongkat Ali (Eurycoma longifolia jack) and its commercial products via UHPLC-QTOF-MS-MS and its protective effect against 5-flurouracil-Induced testicular toxicity in male rats.
J Ethnopharmacol
January 2025
Pharmacognosy Department, Faculty of Pharmacy, The British University in Egypt, Cairo 11837, Egypt.
Article Synopsis
- Tongkat Ali is a special herbal medicine known for helping with sexual health and is sold in many products around the world.
- This study looked at the different chemicals in Tongkat Ali products compared to the real root, and how its extract helps protect against damage caused by a medicine (5FU) in male rats.
- The results showed that Tongkat Ali can improve sperm quality and levels of important hormones while also reducing harmful substances in the body.
Supplementation of sperm cooling medium with Eurycoma longifolia extract enhances native Thai chicken sperm quality and fertility potential.
Front Vet Sci
September 2024
Department of Animal Science, Faculty of Agricultural, Khon Kaen University, Khon Kaen, Thailand.
Cooled semen storage methods result in oxidative stress generated by an imbalance between oxidation rates, specifically reactive oxygen species production, and sperm cell antioxidants, leading to degradation of semen quality. We aimed to investigate the impact of adding Eurycoma longifolia (EL) extract as an antioxidant supplement in semen storage medium (IGGKPh semen extender) on semen quality and fertility potential. EL extract at concentrations of 5, 10, 15, and 20 mg/mL was assessed for its antioxidant capacity in IGGKPh semen extender.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!