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Drug Development.
Alzheimers Dement
December 2024
Critical Path for Alzheimer's Disease (CPAD) Consortium, Critical Path institute, Tucson, AZ, USA.
Background: To help improve the Alzheimer's disease (AD) therapeutics research and development process, the Critical Path for Alzheimer's Disease (CPAD) Consortium at the Critical Path Institute (C-Path) provides a neutral framework for the drug development industry, regulatory agencies, academia, and patient advocacy organizations to collaborate. CPAD's extensive track record of developing regulatory-grade quantitative drug development tools motivates sponsors to share patient-level data and neuroimages from clinical trials. CPAD leverages these data and uses C-Path's core competencies in data management and standardization, quantitative modeling, and regulatory science to develop tools that help de-risk decision making in AD drug development.
View Article and Find Full Text PDFRecombinant Fungal Aspartic Endopeptidases: Insights into Protein Hydrolysis and Combined Effect with Pepsin for Animal Feed Application.
J Agric Food Chem
January 2025
Faculty of Mechanical and Process Engineering, Hochschule Offenburg, 77652 Offenburg, Germany.
Protein hydrolysis under acidic conditions can improve the product quality, nutrient availability, and cost efficiency, particularly when neutral or alkaline enzymes are ineffective. Six fungal aspartic endopeptidases (FAPs) were recombinantly expressed as active enzymes in , with peak activity between 30-50 °C and pH 3.0-4.
View Article and Find Full Text PDFIn situ HO production from self-sufficient heterogeneous Fenton reaction over Fe/MoS for potential environmental remediation applications.
J Colloid Interface Sci
December 2024
Department of Civil and Environmental Engineering, National University of Singapore, 10 Kent Ridge, Singapore. Electronic address:
Fenton reaction technology has worked well in water and wastewater treatment; however it is often limited by such problems as continuous external supply of HO, slow Fe/Fe cycle rate, high energy requirements, and maintenance of low pH during operation. Herein, a novel self-sufficient heterogeneous Fenton system based on Fe/MoS was designed, fabricated, and optimized to effectively address these problems. The combined presence of Fe and sulfur vacancies sites in MoS played a pivotal role in the generation of HOvia two-step single-electron reduction process without any energy consumption.
View Article and Find Full Text PDFMechanism of molecular communication and bacterial community succession in microalgal bacterial biofilms under different photoperiods.
J Environ Manage
December 2024
College of Environmental and Resource Science, College of Carbon Neutral, Zhejiang Agriculture and Forestry University, Hangzhou, 311300, China.
Microalgal-bacterial biofilms are a competitive wastewater treatment technology. This study investigated the impact of photoperiod on the characteristics and performance of these biofilms in treating pig farm wastewater. Under continuous lighting (L-24h), we observed optimal NH-N removal efficiency, minimal chlorophyll levels, and peak concentrations of polysaccharides and c-di-GMP.
View Article and Find Full Text PDFSecondary transport mechanisms in amino acid fed enhanced biological phosphorus removal.
Chemosphere
January 2025
Gerald May Department of Civil, Construction, and Environmental Engineering, The University of New Mexico, Albuquerque, NM, 87131, United States. Electronic address:
Enhanced biological phosphorus removal (EBPR) water resource recovery facilities (WRRFs) often fail to meet phosphorus discharge permit limits, indicating a need to improve EBPR to reduce environmental phosphorus discharges. EBPR designs are largely based on the Accumulibacter polyphosphate accumulating organism (PAO) metabolism, while understudied Tetrasphaera PAOs are equally important to EBPR in many facilities worldwide. Anaerobic organic carbon competition is believed to be a key driver of EBPR reliability.
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