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New 1,3-diphenyl-1-pyrazol-5-ols as anti-methicillin resistant agents: Synthesis, antimicrobial evaluation and studies.
Heliyon
July 2024
Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt.
In the present work, two hybrid series of pyrazole-clubbed pyrimidine and pyrazole-clubbed thiazole compounds from 4-acetyl-1,3-diphenyl-1-pyrazole-5(4)-ole were synthesized as novel antimicrobial agents. Their chemical structures were thoroughly elucidated in terms of spectral analyses such as IR, H NMR, C NMR and mass spectra. The compounds were evaluated for their antimicrobial efficiency against various standard pathogen strains, gram -ive bacteria (, ), gram + ive bacteria (MRSA, ), and Unicellular fungi () microorganisms.
View Article and Find Full Text PDFAnti-MRSA and cytotoxic activities of different solvent extracts from grown in Shubak, Jordan.
Open Vet J
April 2024
Department of Medical Analysis, Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma'an, Jordan.
Background: Globally, resistance to antimicrobial drugs is a major hazard to public health. Infections that were once easily treatable with antibiotics are becoming harder to control, leading to prolonged illnesses, increased mortality rates, and higher healthcare costs.
Aim: This study intended to assess the antimicrobial, specifically the anti-Methicillin resistant (MRSA), and anticancer properties of different extracts obtained from (AHA).
Equinins as Novel Broad-Spectrum Antimicrobial Peptides Isolated from the Cnidarian (Linnaeus, 1758).
Mar Drugs
April 2024
Marine Immunobiology Laboratory, Department of Earth and Marine Sciences (DiSTeM), University of Palermo, Viale delle Scienze, Ed. 16, 90128 Palermo, Italy.
Sea anemones are valuable for therapeutic research as a diversified source of bioactive molecules, due to their diverse bioactive molecules linked to predation and defence mechanisms involving toxins and antimicrobial peptides. Acid extracts from tentacles and body were examined for antibacterial activity against Gram-positive, Gram-negative bacteria, and fungi. The peptide fractions showed interesting minimum inhibitory concentration (MIC) values (up to 0.
View Article and Find Full Text PDFUnveiling the Antimicrobial and Larvicidal Potential of Butyrolactones and Orsellinic Acid Derivatives from the Morus alba-derived Fungus Aspergillus terreus via Integrated In vitro and In silico Approaches.
Chem Biodivers
March 2024
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street 1, 11566, Cairo, Egypt.
The emergence of multi-drug-resistant microbial strains spurred the search for antimicrobial agents; as a result, two distinct approaches were combined: four in vitro studies and four corresponding molecular docking investigations. Antituberculosis, anti-methicillin-resistant Staphylococcus aureus (anti-MRSA), antifungal, and larvicidal activities of the crude extract, two fractions, and seven isolated compounds from Aspergillus terreus derived from Morus alba roots were explored. The isolated compounds (5 butyrolactones and 2 orsellinic acid derivatives) showed potent to moderate antitubercular activity with MIC values ranging from 1.
View Article and Find Full Text PDFNew Pyrazole-Clubbed Pyrimidine or Pyrazoline Hybrids as Anti-Methicillin-Resistant Agents: Design, Synthesis, and Evaluation, and Molecular Modeling Simulation.
ACS Omega
November 2023
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa 11152, Dakahlia, Egypt.
Two hybrid series of pyrazole-clubbed pyrimidines - and pyrazole-clubbed pyrazoline compounds and were designed as attractive scaffolds to be investigated and for antibacterial activity against methicillin-resistant (MRSA) and . From the results of the antibacterial screening, compound showed excellent activity (minimal inhibitory concentration, MIC = 521 μM) when compared with that of the reference antibiotic levofloxacin (MIC = 346 μM). The inhibition of the target dihydrofolate reductase (DHFR) enzyme by compounds and - (IC = 5.
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