Domest Anim Endocrinol
United States Department of Agriculture, University of Missouri, Columbia 65211, USA.
Published: April 1999
Early growth is an important determinant of gain and efficiency in growing pigs. A major limiting factor of piglet growth is feed intake. Orexins, newly discovered neuropeptides, may be important regulators of appetite. The orexin gene, which encodes orexin-A and -B, was recently identified in rodents and man. The objectives of this study were to clone the cDNA for porcine orexin, utilize the cDNA sequence information to produce synthetic hormone, and evaluate the effect of orexin administration on feed intake in weanling pigs. Oligonucleotide primers were designed for reverse transcription polymerase chain reaction production of porcine orexin cDNA. The polymerase-chain-reaction products were cloned, sequenced, and found to be 88.5% homologous to the human orexin sequence. Predicted translation of porcine orexin cDNA revealed orexin-A and -B amino acid sequences that were 100% and 96% homologous to the known human peptides, respectively. Porcine orexin-B was synthesized according to the predicted sequence. Twenty-six cross-bred piglets were utilized in three replicates (n = 8-10/replicate). Piglets were weaned between 2-3 wk of age. One week after weaning, equal numbers of animals in each replicate received intramuscular (i.m.) injections of orexin-B (3 mg/kg body weight) or vehicle (sterile water). Feed intake was monitored from -24 to 24 h relative to injection (time 0). The orexin-injected pigs ingested an additional meal at 12 h when compared with the control animals (P = 0.02). Cumulative feed intake was increased by orexin-B administration from 12 to 24 h postinjection (P < or = 0.05). Total feed intake at 24 h was improved by 18% in orexin-treated pigs (P = 0.05). The ability to stimulate appetite during critical periods of early growth, particularly following weaning, could result in significant improvements in swine-production efficiency.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/s0739-7240(99)00011-9 | DOI Listing |
Trop Anim Health Prod
January 2025
Department of Animal Science, Universidade Estadual de Maringá, Av. Colombo, 5790, Maringá, Paraná, 87020-900, Brazil.
This study was realized to evaluate the influence of monensin, virginiamycin,trace minerals and yeast combination on animal performance, feed efficiency, in situ digestibility, feeding behavior, and carcass and meat characteristics from bulls finished in feedlot fed high-grain diet. A total of 36 (European vs. Nellore) bulls at 24 ± 3.
View Article and Find Full Text PDFDiabetologia
January 2025
MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Aims/hypothesis: UK standard care for type 2 diabetes is structured diabetes education, with no effects on HbA, small, short-term effects on weight and low uptake. We evaluated whether remotely delivered tailored diabetes education combined with commercial behavioural weight management is cost-effective compared with current standard care in helping people with type 2 diabetes to lower their blood glucose, lose weight, achieve remission and improve cardiovascular risk factors.
Methods: We conducted a pragmatic, randomised, parallel two-group trial.
Br J Sports Med
January 2025
The Royal Ballet, Royal Ballet and Opera, London, UK
Poult Sci
January 2025
Department of Poultry Science, Faculty of Agriculture, Tarbiat Modares University, PO Box 14115-336, Iran. Electronic address:
This study was planned and executed to investigate the effects of two levels of compound toxin binder (CTB) on growth performance, serum biochemistry, antioxidant status, intestinal morphology, and the ileal selected microflora population in broiler chickens. A total of 240 one-day-old Ross 308 broiler chickens were divided into four treatments and six replicates (10 chickens per replicate). Experimental groups included; 1, negative control (NC; no aflatoxins (AFs) and no additives); 2, positive control (PC; 490 µg/kg AFs); 3, low levels of compound toxin binder (LCTB), PC + 1 g/kg available CTB (Navacidox); and 4, high levels of compound toxin binder (HCTB), PC + 2 g/kg Navacidox.
View Article and Find Full Text PDFPatient Educ Couns
January 2025
Ohio State University, Dept. of Psychology, Columbus, USA.
Objective: Stage-based models of change posit stage specific factors to promote motivation and intention formation for those not ready to change and volitional action strategies for others. The impact of two interventions on energy restriction and weight change among adults with prediabetes (n = 190) was examined by baseline stage.
Methods: Stage classification included: Pre-intenders had no intention to change; Intenders set an intention but were not acting; and Actors reported eating a low-fat diet at baseline.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.