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Guideline No. 448: Prevention of Rh D Alloimmunization.
J Obstet Gynaecol Can
April 2024
Victoria, BC.
Objective: This guideline provides recommendations for the prevention of Rh D alloimmunization (isoimmunization) in pregnancy, including parental testing, routine postpartum and antepartum prophylaxis, and other clinical indications for prophylaxis. Prevention of red cell alloimmunization in pregnancy with atypical antigens (other than the D antigen), for which immunoprophylaxis is not currently available, is not addressed in this guideline.
Target Population: All Rh D-negative pregnant individuals at risk for Rh D alloimmunization due to potential exposure to a paternally derived fetal Rh D antigen.
Practices for RhD alloimmunization prevention: a vignette-based survey of midwives.
J Matern Fetal Neonatal Med
December 2022
Midwifery Department, Versailles Saint Quentin University, Paris-Saclay University, Montigny-le-Bretonneux, France.
Introduction: Despite the availability guidelines to prevent RhD alloimmunization, severe hemolytic disease of fetus and newborn still occurs in high-income countries. The aim of the study was (1) To assess variations in practices for the prevention of RhD alloimmunization, and (2) to understand midwives' acceptance and appropriation of fetal RhD genotyping.
Methods: Descriptive cross-sectional survey of French midwives from September 2017 through January 2018.
FIGO/ICM guidelines for preventing Rhesus disease: A call to action.
Int J Gynaecol Obstet
February 2021
Worldwide Initiative for Rh Disease Eradication, New York, NY, USA.
The introduction of anti-Rh(D) immunoglobulin more than 50 years ago has resulted in only a 50% decrease in Rhesus disease globally owing to a low uptake of this prophylactic approach. The International Federation of Gynecology and Obstetrics, International Confederation of Midwives, and Worldwide Initiative for Rhesus Disease Eradication have reviewed current evidence regarding the utility of anti-Rh(D) immunoglobulin. Taking into account the effectiveness anti-Rh(D), the new guidelines propose adjusting the dose for different indications and prioritizing its administration by indication.
View Article and Find Full Text PDFFacilitators and barriers for RhD-immunized women to become and remain anti-D donors.
Transfusion
April 2018
Sanquin Research, Department of Donor Studies, Amsterdam, the Netherlands.
Background: The successful introduction of prophylaxis with anti-RhD immunoglobulin has resulted in a significant decline of pregnancy-related RhD immunizations but also has decreased the availability of naturally immunized women as (new) anti-D donors. An influx of new donors is necessary to maintain a sufficient pool of anti-D donors. We investigated motivators, barriers, and predictors for anti-D donorship in RhD-immunized women.
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