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Clinicopathological and molecular features of lung cancers associated with cystic airspaces: an analysis of 34 cases.
J Thorac Dis
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Department of Thoracic Surgery, The Second Hospital of Dalian Medical University, Dalian, China.
Background: Lung cancer associated with cystic airspaces (LCCA) is a rare occurrence and frequently remains undetected in imaging tests. The diagnosis and treatment of this disease are often delayed due to the lack of comprehension. We aimed to clarify clinicopathological characteristics and investigate the molecular features of LCCA patients.
View Article and Find Full Text PDFHigh Intelectin-1 Expression Associated with Aggressive Tumor Behavior and Worse Survival in Rectal Cancer.
Onco Targets Ther
January 2025
Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan.
Background: Multimodal treatment involving preoperative chemoradiotherapy (CRT) followed by surgery is the current standard of care for rectal cancer. Despite advancements, the risk of recurrence, metastasis, and decreased survival remains high. This study aims to evaluate potential biomarkers to stratify prognosis in patients with rectal cancer undergoing preoperative CRT and surgery.
View Article and Find Full Text PDFDevelopment and validation of a nomogram for predicting visceral pleural invasion in patients with early-stage non-small cell lung cancer.
Transl Lung Cancer Res
December 2024
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Visceral pleural invasion (VPI) is associated with a poor outcome in early-stage non-small cell lung cancer (NSCLC). Preoperative prediction of VPI could have an impact on surgical planning. The aim of this study was to establish a nomogram model based on computed tomography (CT) features to predict VPI in early-stage NSCLC.
View Article and Find Full Text PDFTargeting enolase 1 reverses bortezomib resistance in multiple myeloma through YWHAZ/Parkin axis.
J Biomed Sci
January 2025
Department of Hematology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
Background: Enolase 1 (ENO1) is a conserved glycolytic enzyme that regulates glycolysis metabolism. However, its role beyond glycolysis in the pathophysiology of multiple myeloma (MM) remains largely elusive. Herein, this study aimed to elucidate the function of ENO1 in MM, particularly its impact on mitophagy under bortezomib-induced apoptosis.
View Article and Find Full Text PDF[Clinicopathological features and prognosis of rectal neuroendocrine tumor with grade 2].
Zhonghua Zhong Liu Za Zhi
January 2025
Department of Colorectal Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, China State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100021, China.
To explore the clinicopathological features of rectal neuroendocrine tumor (R-NET) G2, identify prognostic factors, and summarize treatment experience. The clinical data of patients diagnosed with R-NET G2 by pathological diagnosis admitted to Cancer Hospital of the Chinese Academy of Medical Sciences from January 2003 to September 2023 were retrospectively analyzed. The Fisher's exact test and Kaplan-Meier curves were performed to analyze the association between pathological features and prognosis.
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