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ObjectiveThis article provides researchers with an illustrative guide for a workshop model that facilitates evidence-informed policy. The Policy Lab model supports collaboration between experts and policymakers; in the example provided, participants considered digital technologies with near-term potential to improve youth mental health care.MethodThe Policy Lab model uses structured workshop activities to explore a policy question, before narrowing the focus on potential answers.
View Article and Find Full Text PDFTargeting on the PI3K/mTOR: a potential treatment strategy for clear cell ovarian carcinoma.
Cancer Chemother Pharmacol
January 2025
Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China.
Purpose: Ovarian clear cell carcinoma is a highly malignant gynecological tumor characterized by a high rate of chemotherapy resistance and poor prognosis. The PI3K/AKT/mTOR pathway is well-known to be closely related to the progression of various malignancies, and recent studies have indicated that this pathway may play a critical role in the progression and worsening of OCCC.
Methods: In this study, we investigated the combined effects of WX390, a dual inhibitor of PI3K/mTOR, and cisplatin on OCCC through both in vitro and in vivo experiments to further elucidate their therapeutic effects.
Construction of a nursing management program for early fluid resuscitation in patients with acute pancreatitis: a Delphi study in China.
BMC Nurs
January 2025
General Surgery Department, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, 99 Longcheng street, Taiyuan, 030032, Shanxi province, China.
Aim And Objectives: To construct a set of scientific and feasible nursing management protocols for early fluid resuscitation in acute pancreatitis (AP) patients that can be used to guide clinical practice and enhance the treatment efficacy in these patients.
Background: Fluid resuscitation is a key means of early treatment for AP patients and has become a clinical consensus. Nurses are important practitioners of fluid resuscitation, and there is a lack of specific enforceable nursing management programs.
Limnobacter olei sp. nov., a Novel Diesel-Degrading Bacterium Isolated from Oil-Contaminated Soil.
Curr Microbiol
January 2025
Jiangsu Longhuan Environmental Science Co. LTD, Changzhou, 213164, China.
A bacterial strain P1, capable of degrading diesel and converting thiosulfate to sulfate was isolated from an oil-contaminated soil sample. The cells were Gram-stain-negative, slightly curved rods and motile with a single polar flagellum. Growth of the strain was observed at 4-45 °C (optimum at 28 °C), at pH 4.
View Article and Find Full Text PDFThe Gift of Time, How Do I Want to Spend It? Exploring Preferences for Time Allocation Among Women with and without a Breast Cancer Diagnosis.
Appl Health Econ Health Policy
December 2024
Health Systems and Health Economics, School of Public Health, Curtin University, Bentley, Perth, Australia.
Background: Women's preferences for time allocation reveal how they would like to prioritise market work, family life, and other competing activities. Whilst preferences may not always directly translate to behaviour, they are an important determinant of intention to act.
Objective: We present the first study to apply a discrete choice experiment (DCE) to investigate time allocation preferences among women diagnosed with breast cancer and women without a cancer diagnosis.
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