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Numerous studies have reported benefits of music listening to support learning and motor rehabilitation. In the case of handwriting, previous studies suggested that musical background improves movement speed and fluency. Whether this benefit comes from the melody or is specifically related to the rhythmic cues provided by the music remains to be established.

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Nutraceuticals and Supplements in Management of Prediabetes and Diabetes.

Nutrients

December 2024

SINut-Società Italiana di Nutraceutica, Via Guelfa, 9, 40138 Bologna, Italy.

Dysglycemia is a condition preceding diabetes mellitus. The two situations inherent in this condition are called impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). If one of these situations is found in the patient, after the advice of an appropriate diet and physical activity, the addition of nutraceuticals or supplements can be considered, which can stop or delay the progression to diabetes mellitus over time.

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Functionalized DNA secondary structures and nanostructures for specific protein modifications.

Trends Biochem Sci

December 2024

Laboratory of Organic Chemistry, Wageningen University and Research, Stippeneng 4, 6708, WE, Wageningen, The Netherlands. Electronic address:

The development of non-biological applications of DNA has not only resulted in delicately shaped DNA-based nano-objects with complex functions but also spawned their use for novel catalytic applications. From the multitude of applications of DNAzymes that operate on a relatively simple substrate, we have witnessed the emergence of multifunctional catalytically active DNA-based nanostructures for one of the most challenging tasks known to a chemist: the controlled and precise modification of a wild-type protein in its natural environment. By incorporating various elements associated with post-translational modification (PTM) writer enzymes into complex nanostructures, it is now possible to chemically modify a specific protein in cell lysates under the influence of an externally added trigger, clearly illustrating the promising future for this approach.

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Movies often use allusions to add depth, create connections, and enrich the storytelling. However, translators may face challenges when subtitling movie allusions, as they must render both meaning and culture accurately despite existing language and cultural barriers. These challenges could be further complicated by the use of available AI tools attempting to subtitle movie allusions, while probably unaware of existing cultural complexities.

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Post-Translational Modifications of RNA-Modifying Proteins in Cellular Dynamics and Disease Progression.

Adv Sci (Weinh)

November 2024

Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.

RNA-modifying proteins, classified as "writers," "erasers," and "readers," dynamically modulate RNA by adding, removing, or interpreting chemical groups, thereby influencing RNA stability, functionality, and interactions. To date, over 170 distinct RNA chemical modifications and more than 100 RNA-modifying enzymes have been identified, with ongoing research expanding these numbers. Although significant progress has been made in understanding RNA modification, the regulatory mechanisms that govern RNA-modifying proteins themselves remain insufficiently explored.

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