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Autophagy-Enhancing Properties of Extracts in HaCaT Keratinocytes: Potential as an Anti-Photoaging Cosmetic Ingredient.
Molecules
January 2025
Graduate School of Biotechnology, Kyung Hee University, Yongin-si 17104, Republic of Korea.
The decline in autophagy disrupts homeostasis in skin cells, leading to oxidative stress, energy deficiency, and inflammation-all key contributors to skin photoaging. Consequently, activating autophagy has become a focal strategy for delaying skin photoaging. Natural plants are rich in functional molecules and widely used in the development of anti-photoaging cosmetics.
View Article and Find Full Text PDFCobalt Protoporphyrin Downregulates Hyperglycemia-Induced Inflammation and Enhances Mitochondrial Respiration in Retinal Pigment Epithelial Cells.
Antioxidants (Basel)
January 2025
Graduate Institute of Biomedical Engineering, National Chung-Hsing University, Taichung 402, Taiwan.
Diabetic retinopathy is characterized by hyperglycemic retinal pigment epithelial cells that secrete excessive pro-inflammatory cytokines and VEGF, leading to retinal damage and vision loss. Cobalt protoporphyrin (CoPP) is a compound that can reduce inflammatory responses by inducing high levels of HO-1. In the present study, the therapeutic effects of CoPP were examined in ARPE-19 cells under hyperglycemia.
View Article and Find Full Text PDFProtocol for real-time assessment of energy metabolism in dissociated mouse retinal photoreceptors using a SeahorseXFe24 analyzer.
STAR Protoc
January 2025
Department of Ophthalmology and Ross Eye Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA. Electronic address:
Defects in retinal metabolism have been linked to the onset and progression of various retinal diseases. Herein, we provide a protocol for measuring bioenergetics in dissociated mouse retinal photoreceptors. We outline detailed instructions for obtaining morphologically intact and viable photoreceptor cells from adult mice and preparing the cells for metabolic analysis using a SeahorseXFe24 analyzer.
View Article and Find Full Text PDFA novel breath pattern model and analysis to minimize patient discomfort in medical ventilators.
Sci Rep
January 2025
Department of Mechanical Engineering, PSG Institute of Technology and Applied Research, Coimbatore, 641026, India.
Typical waveforms used for the simulation of pressure and volume-controlled ventilation in medical ventilators have been extensively studied in the literature. The majority of simulation studies reported employ the step pattern or ramp pattern to model the pressure and flow variations in pressure/volume-controlled ventilation. It was observed that the above waveforms tend to add to the discomfort level of patients due to the presence of jerks in derivatives of pressure/flow variations; the pressure/flow variation of air and oxygen mixture should be smooth so that the patient discomfort is kept at a minimal level.
View Article and Find Full Text PDFDNA methylation of long noncoding RNA cytochrome B in diabetic retinopathy.
Noncoding RNA Res
April 2025
Kresge Eye Institute, Wayne State University, Detroit, MI, USA.
Diabetic retinopathy, a microvascular complication of diabetes, is the leading cause of blindness in adults, but the molecular mechanism of its development remains unclear. Retinal mitochondrial DNA is damaged and hypermethylated, and mtDNA-encoded genes are downregulated. Expression of a long noncoding RNA (larger than 200 nucleotides, which does not translate into proteins), encoded by mtDNA, cytochrome B (Lnc), is also downregulated.
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