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Retroperitoneal liposarcomas(RPL) are rare malignant tumors, accounting for approximately 15% of soft tissue sarcomas and 0.07-0.2% of all cancers.

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Retroperitoneal leiomyosarcoma diagnosis and management in a chronic kidney disease context: A case report.

Int J Surg Case Rep

November 2024

Department of Surgery A La Rabta Hospital, Tunis, Tunisia; Faculty of medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Introduction And Importance: While the treatment approach for sarcomas seems straightforward and well-defined, we often encounter several diagnostic or therapeutic challenges in clinical practice. This article presents a case of retroperitoneal leiomyosarcoma in a patient with chronic kidney disease, highlighting the complexity of managing such cases.

Case Report: A 63-year-old woman with a history of chronic kidney disease presented with a progressively enlarging mass in her right flank.

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Article Synopsis
  • Retroperitoneal liposarcomas (RPLPSs) are uncommon tumors arising from mesenchymal cells in the peritoneal cavity, with renal cases being especially rare; only 45 instances have been documented.* -
  • A case study of a 44-year-old woman revealed that she had RPLPS, identified due to symptoms like hirsutism and an abdominal mass, which was confirmed via imaging and needle biopsy; she successfully underwent surgery.* -
  • RPLPSs are primarily asymptomatic until they grow large, categorized into five subtypes, and while they seldom metastasize, they often recur; they can compress nearby structures like the adrenal gland.*
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Unexpected Extrarenal Accumulation of Tc-99m Ethylene Dicysteine in a Case of Liposarcoma.

Indian J Nucl Med

August 2024

Department of Nuclear Medicine, School of Medicine, Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Article Synopsis
  • Tc-99m EC is a radiopharmaceutical used in renal scintigraphy to evaluate kidney function and detect urinary tract obstructions.
  • A case study describes a 70-year-old man with recurrent abdominal liposarcoma exhibiting unusual Tc-99m EC uptake outside the kidneys.
  • The lesions identified via abdominal CT scan showed a heterogeneous accumulation of Tc-99m EC, indicating a possible link between the radiopharmaceutical and the presence of liposarcoma.
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Article Synopsis
  • Retroperitoneal liposarcoma (RPLPS) is a rare and challenging cancer, especially when it's larger than 30 cm, which complicates diagnosis and treatment.
  • A 58-year-old male was diagnosed with a giant RPLPS measuring 55 cm, which had invaded surrounding organs; he underwent successful surgical resection and was discharged with no recurrence after 6 months.
  • Surgery is the most effective treatment for RPLPS, emphasizing the importance of detailed preoperative evaluations, while the necessity of additional therapies like radiotherapy or chemotherapy remains debated.
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