The polymorphism of two natural populations of snails, Biomphalaria tenagophila, from São José dos Campos, São Paulo State (SJ) and from Núcleo Bandeirante, Distrito Federal (BN), was studied with respect to esterase and alcohol dehydrogenase (ADH) zymograms. The two population zymograms do not differ qualitatively. However the high frequency of esterase a and b bands in SJ and of e,f and h in NB, is a diagnostic mark. Moreover, frequency of band e alone can be used to distinguish the two populations. The high frequency of 3-banded ADH phenotype is a diagnostic mark of the SJ population.

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