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Left atrial shunting devices: why, what, how, and… when?
Heart Fail Rev
January 2025
Department of Cardiology, San Luca Hospital, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Left atrial (LA) hypertension is central in the pathophysiology of heart failure (HF) in general and of HF with preserved ejection fraction (HFpEF) in particular. Despite approved treatments, a number of HF patients continue experiencing disabling symptoms due to LA hypertension, causing pulmonary congestion, pulmonary hypertension, and right heart dysfunction, at rest and/or during exercise. LA decompression therapies, i.
View Article and Find Full Text PDFPurpose: To evaluate the effect of osilodrostat and hypercortisolism control on blood pressure (BP) and glycemic control in patients with Cushing's disease.
Methods: Pooled analysis of two Phase III osilodrostat studies (LINC 3 and LINC 4), both comprising a 48-week core phase and an optional open-label extension. Changes from baseline in systolic and diastolic BP (SBP and DBP), fasting plasma glucose (FPG), and glycated hemoglobin (HbA) were evaluated during osilodrostat treatment in patients with/without hypertension or diabetes at baseline.
Efficient and Rapid Microfluidics Production of Bio-Inspired Nanoparticles Derived from Silkworm for Enhanced Breast Cancer Treatment.
Pharmaceutics
January 2025
School of Medicine and Population Health, The University of Sheffield, Barber House, Sheffield S10 2HQ, UK.
: In the quest for sustainable and biocompatible materials, silk fibroin (SF), derived from natural silk, has emerged as a promising candidate for nanoparticle production. This study aimed to fabricate silk fibroin particles (SFPs) using a novel swirl mixer previously presented by our group, evaluating their characteristics and suitability for drug delivery applications, including magnetic nanoparticles and dual-drug encapsulation with curcumin (CUR) and 5-fluorouracil (5-FU). : SFPs were fabricated via microfluidics-assisted desolvation using a swirl mixer, ensuring precise mixing kinetics.
View Article and Find Full Text PDFCellulose-Based Aerogels for Environmentally Sustainable Applications: A Review of the Production, Modification, and Sorption of Environmental Contaminants.
Polymers (Basel)
January 2025
Environmental Sciences Postgraduate Program, Center of Engineering, Federal University of Pelotas, R. Benjamin Constant 989, Pelotas 96010-020, RS, Brazil.
Environmental pollution, stemming from the disposal of contaminants, poses severe threats to ecosystems and human health. The emergence of a new class of pollutants, termed emerging contaminants (ECs), in soil, water, and air has raised global concerns, aligning with the UN 2030 Agenda's Sustainable Development Goals. Aerogels, three-dimensional structures with high porosity and low density, offer promise in addressing this issue.
View Article and Find Full Text PDFExploring a Software Framework for Posture Tracking and Haptic Feedback Control: A Virtual Reality-Based Approach for Upper Limb Rehabilitation on the Oculus Quest 2.
Sensors (Basel)
January 2025
2Ai, School of Technology, IPCA, 4750-810 Barcelos, Portugal.
Virtual reality (VR) has gained significant attention in various fields including healthcare and industrial applications. Within healthcare, an interesting application of VR can be found in the field of physiotherapy. The conventional methodology for rehabilitating upper limb lesions is often perceived as tedious and uncomfortable.
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