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Studying the Oncolytic Activity of Strains Against Hepatoma, Glioma, and Pancreatic Cancer and .
Microorganisms
January 2025
Scientific and Educational Center, Molecular Bases of Interaction of Microorganisms and Human of the Center for Personalized Medicine of Federal State Budgetary Scientific Institution, Institute of Experimental Medicine, Acad. Pavlov Street, 12, 197022 Saint Petersburg, Russia.
Background: Cancer remains a leading cause of mortality globally. Conventional treatment modalities, including radiation and chemotherapy, often fall short of achieving complete remission, highlighting the critical need for novel therapeutic strategies. One promising approach involves the oncolytic potential of Group A (GAS) strains for tumor treatment.
View Article and Find Full Text PDFStress and Traditional Support: The Role of Orphans' and Vulnerable Children's Primary Caregivers in Rural Ethiopia.
Children (Basel)
January 2025
College of Public Health and Social Justice, Saint Louis University, St. Louis, MO 63103, USA.
Background/objectives: Orphans' and Vulnerable Children's (OVC) primary caregivers (PCGs) in Ethiopia live with multiple social and emotional problems stemming from extreme poverty, war, environmental disasters, and the HIV pandemic. Family and community supports are strained, leaving OVC's PCGs dependent on inconsistent humanitarian aid. This aid is typically focused on OVCs and does not address PCG well-being.
View Article and Find Full Text PDFThe extent of western lowland gorilla social relationships within and between groups.
PLoS One
January 2025
Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo, Chicago, Illinois, United States of America.
The nature of western lowland gorilla social relationships within and between groups is largely understudied, partly due to the challenges of monitoring associations between individuals who live in neighboring groups. In this study, we examined the social relationships of four western lowland gorilla groups in the Ndoki landscape of northern Republic of Congo. To do so, we compiled all-occurrence social interaction and silverback nearest neighbor social networks from data collected during daily group follows conducted over several years.
View Article and Find Full Text PDFLong-acting reversible and permanent contraceptives utilization and its associated factors among married women who desire no more children in Ethiopia: A multilevel analysis.
PLoS One
January 2025
Department of General Midwifery, School of Midwifery, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Objective: This study aimed to investigate long-acting reversible and permanent contraceptives (LARPCs) utilization and its associated factors among married women who desire no more children in Ethiopia.
Methods: Secondary datasets from the 2016 Ethiopian Demographic and Health Survey was used for the study. A total weighted sample of 3,756 married or in union reproductive age women who desire no more children were included in the analysis.
Elegant and Innovative Recoding Strategies for Advancing Vaccine Development.
Vaccines (Basel)
January 2025
Department of Veterinary Microbiology and Immunology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada.
Recoding strategies have emerged as a promising approach for developing safer and more effective vaccines by altering the genetic structure of microorganisms, such as viruses, without changing their proteins. This method enhances vaccine safety and efficacy while minimizing the risk of reversion to virulence. Recoding enhances the frequency of CpG dinucleotides, which in turn activates immune responses and ensures a strong attenuation of the pathogens.
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