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Real-world outcomes of first-line maintenance niraparib monotherapy in patients with epithelial ovarian cancer.
Future Oncol
January 2025
Division of Gynecologic Oncology, The Ohio State University Wexner Medical Center and James Hospital Comprehensive Cancer Center, Columbus, OH, USA.
Aims: To assess real-world progression-free survival (rwPFS) and time to next treatment (rwTTNT) among patients with epithelial ovarian cancer (EOC) who received first-line maintenance (1LM) niraparib monotherapy.
Patients & Methods: In this US-nationwide, electronic health record-derived, deidentified database study, eligible patients with EOC initiated 1LM niraparib monotherapy (1 January 2017-1 December 2022) following first-line platinum-based chemotherapy. Median rwPFS and rwTTNT were estimated with Kaplan-Meier methodology overall and in a homologous recombination-deficient (HRd) subgroup (further stratified as wild-type [wt] or -mutated [m]).
Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway.
Cell Death Differ
December 2024
Department of Pathology, The University of Michigan, Ann Arbor, MI, USA.
The integrated stress response (ISR) regulates cell fate during conditions of stress by leveraging the cell's capacity to endure sustainable and efficient adaptive stress responses. Protein phosphatase 2A (PP2A) activity modulation has been shown to be successful in achieving both therapeutic efficacy and safety across various cancer models. However, the molecular mechanisms driving its selective antitumor effects remain unclear.
View Article and Find Full Text PDFNaivety dies with the calf: calf loss to human hunters imposes behavioral change in a long-lived but heavily harvested ungulate.
Mov Ecol
September 2024
Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Skogsmarksgränd, 901 83, Umeå, Sweden.
Article Synopsis
- The study investigates how losing offspring to hunters affects the behavior of moose, particularly in terms of habitat selection and movement patterns.
- It combines movement data from 51 adult female moose with information about their offspring survival to analyze changes in behavior after calf harvest.
- Results indicate that female moose adjust their habitat choices and movement distances following the loss of a calf, displaying more caution in their proximity to roads and human settlements.
In times in which climate change is becoming increasingly noticeable in the everyday lives of the global population, a rethinking towards an environmentally friendly and climate-neutral way of life is essential in all areas of human activity (including medicine). In the field of nephrology, a reorientation of resource-intensive renal replacement therapy is therefore absolutely necessary, keyword "green nephrology". To this end, awareness of the CO emissions caused in the field of nephrology must first be raised so that CO savings can then be implemented efficiently.
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