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Cell therapy for scleroderma: progress in mesenchymal stem cells and CAR-T treatment.
Front Med (Lausanne)
January 2025
Department of Rheumatology and Immunology, Qinzhou First People's Hospital, Qinzhou, Guangxi, China.
Cell therapy is an emerging strategy for precision treatment of scleroderma. This review systematically summarizes the research progress of mesenchymal stem cell (MSC) and chimeric antigen receptor T cell (CAR-T) therapies in scleroderma and discusses the challenges and future directions for development. MSCs possess multiple functions, including immunomodulation, anti-fibrosis, and promotion of vascular regeneration, all of which can improve multiple pathological processes associated with scleroderma.
View Article and Find Full Text PDFAssociation between neutrophil-to-high-density lipoprotein cholesterol ratio and non-alcoholic fatty liver disease or metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2017-2020.
Front Med (Lausanne)
January 2025
Center of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Background: Non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with chronic inflammation and lipid metabolism disorders. The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is an integrative marker reflecting inflammatory responses and lipid metabolism disorders and is associated with various diseases. This cross-sectional study aimed to determine the association between NHR and NAFLD, MASLD, and liver fibrosis.
View Article and Find Full Text PDFImpact of straw returning on soil ecology and crop yield: A review.
Heliyon
January 2025
National Key Laboratory of Cotton Bio-breeding and Integrated Utilization, State Key Laboratory of Crop Stress Adaptation and Improvement, Key Laboratory of Plant Stress Biology, School of Life Sciences, Henan University, 85 Minglun Street, Kaifeng, 475001, China.
Several studies have demonstrated the effect of straw return on enhancing soil ecology, promoting sustainable agricultural practices, and cumulative effects on plant yield. Recent studies have focused on straw return methods and their impact on soil nutrient cycling and the overall physicochemical composition of the soil. Despite the substantial progress and successes, several research gaps in these studies require further investigations to harness the full potential of straw return.
View Article and Find Full Text PDFEvaluating the dynamics of fee-free higher education in South Africa: a causal loop diagram approach .
F1000Res
January 2025
Industrial Engineering, Tshwane University of Technology, Pretoria, Gauteng, 0183, South Africa.
Background: This research investigated the dynamics of fee-free higher education in South Africa, analysing the interplay of socioeconomic, political, and institutional factors to elucidate the complexities surrounding its implementation and impact. Using a causal loop diagram approach (CLD), the study aims to identify key factors to effective implementation, how they interact to shape the outcome of the policy, and actionable strategies to address the challenges hindering the policy sustainability.
Method: A participatory approach was used to developing the CLD, integrating insights from an extensive literature review and stakeholder opinion.
Fiber Sorbents - A Versatile Platform for Sorption-Based Gas Separations.
Acc Mater Res
January 2025
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30322, United States.
Increasing demand for high-purity fine chemicals and a drive for process intensification of large-scale separations have driven significant work on the development of highly engineered porous materials with promise for sorption-based separations. While sorptive separations in porous materials offer energy-efficient alternatives to longstanding thermal-based methods, the particulate nature of many of these sorbents has sometimes limited their large-scale deployment in high-throughput applications such as gas separations, for which the necessary high feed flow rates and gas velocities accrue prohibitive operational costs. These processability limitations have been historically addressed through powder shaping methods aimed at the fabrication of structured sorbent contactors based on pellets, beads or monoliths, commonly obtained as extrudates.
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