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Loss of N-6 adenine-specific DNA methyltransferase 1 leads to meiotic prophase abnormalities and male sub-fertility in mice.
Biol Reprod
March 2025
The Institute of Cardiovascular Sciences, School of Basic Medical Sciences; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Mammalian sexual reproduction critically relies on the generation of haploid gametes following a specialized cell division process known as meiosis. Here, we demonstrate that N-6 Adenine-Specific DNA methyltransferase 1 (N6AMT1) plays a crucial role in the progression of meiosis during spermatogenesis, as follows. N6AMT1 was expressed in germ cells throughout the entire process of spermatogenesis, with a peak in mRNA levels in spermatocytes at the prophase I stage of meiosis.
View Article and Find Full Text PDFThe association between living environment and out-of-hospital cardiac arrest risk in adults: the perspective of daily-life contexts.
Arch Public Health
March 2025
School of Geography and Planning, Sun Yat-Sen University, Guangzhou, China.
Background: Studying the spatial pattern of out-of-hospital cardiac arrest (OHCA) and its environmental impactors is crucial for both providing timely medical assistance and implementing preventative measures. Existing researches have mainly focused on natural and sociodemographic environments, usually at a macro- or meso-scale, while giving less attention to understanding the association between environment and OHCA risk from the perspective of daily-life contexts.
Methods: In this study, we utilized 1843 eligible OHCA cases from core districts of Beijing in 2020 and employed modified Besag-York-Mollié (BYM2) Bayesian models to investigate the association between living environment (consisting of food environment, physical activity environment, healthcare environment and leisure environment) and adult OHCA risk, as well as its age disparities, at a 1 × 1 km cell resolution.
Background: The perioperative management of patients undergoing cardiac surgery is highly complex and involves numerous factors. There is a strong association between cardiac surgery and perioperative complications. The Brazilian Surgical Identification Study (BraSIS 2) aims to assess the incidence of death and early postoperative complications, identify potential risk factors, and examine both the demographic characteristics of patients and the epidemiology of cardiovascular procedures.
View Article and Find Full Text PDFA case of fatal acute saddle embolism of the terminal aorta after long-term support using Impella CP.
J Artif Organs
March 2025
Department of Cardiovascular Surgery, The Sakakibara Heart Institute of Okayama, 2-5-1 Nakaicho, Kita-ku, Okayama, 700-0804, Japan.
A 69-year-old male diagnosed with subacute myocardial infarction was subsequently transferred to our institution. Upon admission, echocardiography revealed ventricular septal rupture (VSR). The patient was promptly supported via venoarterial (VA) extracorporeal membrane oxygenation (ECMO) and Impella CP before surgical VSR repair on the 12th day of admission.
View Article and Find Full Text PDFAcute respiratory failure in influenza as a cause of out-of-hospital cardiac arrest.
Klin Mikrobiol Infekc Lek
June 2024
Clinic of Infectious Diseases and Travel Medicine, University Hospital Pilsen, Czech Republic, e-mail:
Influenza is an infectious disease caused by influenza A, B, and sometimes C viruses. The disease is preventable in all age groups thanks to annual seasonal vaccination. Population groups at high risk of severe illness with complications include seniors, pregnant women, and young children.
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