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Posterior nasal nerve neurolysis in addition to radiofrequency ablation of the inferior turbinates for patients with chronic rhinitis.
ORL J Otorhinolaryngol Relat Spec
January 2025
Introduction: This study aimed to evaluate the outcome of radiofrequency ablation of the inferior turbinates (RFIT) combined with posterior nasal nerve neurolysis (RPN3) in comparison with RFIT alone in the treatment of patients with chronic rhinitis unresponsive to pharmacological therapy.
Methods: A retrospective cohort study was conducted on adult and adolescent patients with chronic rhinitis who demonstrated a poor response to medication. Patients with a total 24-hour reflective total nasal symptom score (rTNSS) of ≧5, rhinorrhea score of ≧2, and congestion score of ≧2 were included.
Determination of the Bioavailability of 3 Intranasal Formulations of Azelastine Hydrochloride in Healthy Male Volunteers.
Clin Pharmacol Drug Dev
January 2025
Allergy & Asthma Solutions, Coto de Caza, CA, USA.
The primary objective of the study was to determine the bioavailability of 2 new formulations of azelastine (AZE) hydrochloride (0.10% and 0.15% AZE) containing sorbitol and sucralose compared with the commercially available 0.
View Article and Find Full Text PDFSpontaneous cerebrospinal fluid rhinorrhea as a primary presentation of idiopathic intracranial hypertension, management strategies, and clinical outcome.
Surg Neurol Int
December 2024
Department of Neurosurgery, Assiut University, Assiut, Egypt.
Background: Causes of cerebrospinal fluid (CSF) rhinorrhea could be divided into primary (spontaneous) and secondary (head trauma and iatrogenic). Idiopathic intracranial hypertension (IIH) has emerged as a cause for spontaneous CSF rhinorrhea but is still underestimated, may be overlooked and needs special consideration in management. The objective of this study is to demonstrate spontaneous CSF rhinorrhea as the primary presentation of IIH and explore the algorithm of management.
View Article and Find Full Text PDFRhinorrhea Recurrence After Posterior Nasal Nerve Cryoablation: A Multicenter Cohort Study.
Laryngoscope
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of California Irvine, Orange, California, U.S.A.
Background: Posterior nasal nerve (PNN) cryoablation improves chronic rhinitis (CR) symptoms in 70-80% of cases, including clear thin rhinorrhea (CTR). This study's purpose was to determine time to and degree of CTR recurrence following cryoablation.
Methods: A multicenter retrospective cohort study was conducted on patients who underwent PNN cryoablation to treat CR-related CTR refractory to ipratropium bromide nasal spray (IBNS).
Chronic Rhinitis Surgery: Association Between Preoperative Severity and Response Rate.
Am J Rhinol Allergy
January 2025
College of Artificial Intelligence, National Yang Ming Chiao Tung University, Tainan, Taiwan.
Background: The success rate of chronic rhinitis surgery varies depending on the patients' factor and surgical method. While outcomes for nasal obstruction differ, the association between preoperative severity of other rhinitis symptoms, such as rhinorrhea, sneezing, and nasal itching, measured via the reflective total nasal symptom score (rTNSS) remains unevaluated.
Objective: To evaluate the association between the response rate to surgical treatment of chronic rhinitis and preoperative severity.
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