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Predicting pathological tumor volume in prostate cancer lesions: A head-to-head comparison of micro-ultrasound vs. MRI.
Urol Oncol
March 2025
Department of Urology, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:
Background And Objective: Our objective was to evaluate the agreement between micro-ultrasound, MRI and pathological tumor and prostate volume.
Methods: Retrospective analysis of consecutive prostate cancer patients with MRI and micro-ultrasound diagnostic assessment who subsequently underwent radical prostatectomy. Tumor and prostate volume on micro-ultrasound and MRI imaging calculated by a dedicated software were compared to those of the prostatectomy specimen.
Measurements of tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots of people receiving pre-exposure prophylaxis for HIV with co-formulated tenofovir disoproxil fumarate and emtricitabine.
J Microbiol Immunol Infect
March 2025
School of Pharmacy, National Taiwan University College of Medicine, Taipei, Taiwan; The Metabolomics Core Laboratory, Center of Genomic and Precision Medicine, National Taiwan University, Taipei, Taiwan; Department of Pharmacy, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:
Background/purpose(s): Data regarding the concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in the Asian population receiving pre-exposure prophylaxis (PrEP) for HIV with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) (TDF/FTC) are limited, and the associations between the frequency of TDF/FTC administration and drug concentration among people receiving on-demand PrEP remain unclear.
Methods: Fifty-seven participants receiving daily TDF/FTC and 113 participants receiving on-demand TDF/FTC were enrolled in this study. The concentrations of TFV-DP and FTC-TP were measured in dried blood spots using liquid chromatography‒mass spectrometry.
Sex-specific optimal cut-off points for metabolic health indicators to predict incident type 2 diabetes mellitus.
Nutr Metab Cardiovasc Dis
February 2025
College of Public Health, University of South Florida, Tampa, FL, USA. Electronic address:
Background And Aim: We aimed to determine the optimal cut-off points for metabolic health indicators, including insulin resistance (IR), glucose, insulin, BMI, and waist circumference, in middle-aged nondiabetic people to predict future type 2 diabetes mellitus (T2DM).
Methods And Results: The data came from 12,543 Atherosclerosis Risk Communities Study participants, including 5758 men and 6785 women. They did not have diabetes at baseline and were followed for incident T2DM within 3, 6, and 9 years.
Effect of brief intense stair climbing on cardiorespiratory fitness and metabolic risk factors in inactive young men with obesity: A randomized controlled trial.
Nutr Metab Cardiovasc Dis
February 2025
Division of Sports Medicine and Science, Graduate School of Physical Education, Kyung Hee University, Yongin, 17104, Republic of Korea; Obesity and Physical Activity Research Laboratory, Kyung Hee University, Yongin, 17104, Republic of Korea. Electronic address:
Background And Aim: We investigated the effects of brief, intense stair climbing on cardiorespiratory fitness (CRF) and cardiometabolic risk factors in young Korean men with obesity.
Methods And Results: Twenty-four healthy men (age: 25.8 ± 2.
Drug-drug interactions in metastatic hormone-sensitive prostate cancer (mHSPC): practical considerations for treating men with androgen receptor pathway inhibitors and common medications in this stage.
Expert Opin Drug Metab Toxicol
March 2025
Department of Pharmacy, Hospital Del Mar, Barcelona, Spain.
Introduction: New androgen receptor pathway inhibitors (ARPIs) are an essential part of the treatment strategy for patients with metastatic hormone-sensitive prostate cancer (mHSPC). Despite the good tolerability of ARPIs, after treatment is started, drug-drug interactions (DDIs) between these and other medications frequently taken by these patients may appear. DDIs may reduce the therapeutic effect of both and lead to increased adverse events.
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