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Pan-cancer analysis combined with experimental validation revealed that is an immunological and prognostic biomarker.
Transl Cancer Res
November 2024
Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Kinectin 1 () is a membrane protein involved in intracellular organelle motility. However, the role of in human pan-cancer lacks systematic analysis and evaluation. The aim of this study is to evaluate the expression profile and clinical value in human cancers by performing a pan-cancer analysis of .
View Article and Find Full Text PDFContemplating the prognostic and therapeutic potential of CD19: a comprehensive analysis across diverse cancer types.
Am J Transl Res
November 2024
Department of General Practice, Pingjiang New Town Community Health Service Center Sujin Street, Gusu District, Suzhou 215000, Jiangsu, China.
Background: Cancer represents a highly intricate disease, characterized by the uncontrolled proliferation and invasion of aberrant cells, leading to widespread global morbidity and mortality. This study investigates the influence of CD19, a marker specific to B-cells, within the tumor microenvironment (TME) across a spectrum of cancer types.
Methodology: To explore the role of CD19, we employed a wide array of bioinformatics tools and databases, including UALCAN, GEPIA2, univariate Cox regression, KM plotter, HPA, GSCA, cBioPortal, TISIDB, and DAVID.
Synchronous bilateral adrenalectomy for ACTH-independent Cushing's syndrome in children: multidisciplinary management.
Eur J Endocrinol
November 2024
Department of Pediatric Surgery and Urology, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, 149 Rue de Sèvres, 75015 Paris, France.
Objective: Adreno CorticoTropic Hormone (ACTH)-independent Cushing's syndrome (CS) in children is very rare but potentially fatal. In bilateral nodular hyperplasia, synchronous bilateral adrenalectomy (SBA) represents the definitive treatment to correct hypercortisolism. We aim to report the multidisciplinary management of this rare condition.
View Article and Find Full Text PDFPolystyrene microplastics disrupt adrenal steroid synthesis in male mice via mitochondrial dysfunction.
Ecotoxicol Environ Saf
December 2024
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China. Electronic address:
Microplastics have gained significant social attention, as they can enter our bodies through food and drinking water. The adrenal gland is essential for the maintenance of metabolic homeostasis and stress responses. Nevertheless, the effects of microplastics on the steroid synthesis in the adrenal cortex was still unclear.
View Article and Find Full Text PDFDevelopment and Characterization of 3-Dimensional Cell Culture Models of Adrenocortical Carcinoma.
Endocrinology
November 2024
Discipline of Pharmacology and Therapeutics, School of Medicine, University of Galway, Galway, H91 V4AY, Ireland.
Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex that is associated with a poor prognosis. Developing effective treatment options for ACC is challenging owing to the current lack of representative preclinical models. This study addressed this limitation by developing and characterizing 3-dimensional (3D) cell cultures incorporating the ACC cell lines, MUC-1, HAC15, and H295R in a type I collagen matrix.
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