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The diagnostic dilemma of adrenal vascular tumors: analysis of 21 cases and systematic review of the literature.
Endocrine
January 2025
Anatomic Pathology - Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy.
Purpose: Adrenal vascular tumors are mainly represented by adrenal cavernous hemangiomas (ACHs) and adrenal cystic lymphangiomas (ACLs). Their radiological features often overlap with malignant tumors, therefore ruling out malignancy becomes mandatory. We analyzed clinical, radiological, and histopathological data to identify specific characteristics of these tumors.
View Article and Find Full Text PDFThe melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families.
J Ovarian Res
December 2024
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA.
Article Synopsis
- - Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women, influenced by genetic and environmental factors, especially connected to the hypothalamic-pituitary-adrenal (HPA) axis genes.
- - A study investigated various single nucleotide polymorphisms (SNPs) in five melanocortin receptor genes within 212 Italian families with PCOS, finding significant associations with certain SNPs in MC1R, MC2R, MC3R, and MC5R.
- - This research highlights the role of specific melanocortin receptor genes in PCOS, marking a new connection, while emphasizing the need for further functional studies to confirm these findings.
Comprehensive Analysis of Mitotane-Related Adverse Events Using the Food and Drug Administration Adverse Event Reporting System.
Endocr Pract
November 2024
Department of Urology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Electronic address:
Objective: Mitotane is currently the only product approved by the Food and Drug Administration for the treatment of adrenocortical cancer. However, there is a lack of comprehensive studies on the adverse events of mitotane.
Methods: Adverse event reports for mitotane in the Food and Drug Administration Adverse Event Reporting System database since 2004 were collected and analyzed to identify mitotane as the primary suspect drug.
Retroperitoneal bronchogenic cyst: a case report and literature review.
Front Oncol
October 2024
Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Introduction: Retroperitoneal bronchogenic cyst, typically situated in the subdiaphragmatic region, is a rare congenital benign developmental abnormality arising from dysplasia of the foregut and abnormal budding of the tracheobronchial tree. Due to its low incidence, there are limited reports regarding this condition.
Case Presentation: Four retroperitoneal bronchogenic cysts near the left adrenal gland were identified without accompanying clinical symptoms.
Common incidental urological lesions on computed tomography images: What to do with renal and adrenal computed tomography incidentalomas in a primary care setting.
Aust J Gen Pract
November 2024
MBBS, PhD, FRACS (Urol), Professor, Department of Surgery, The University of Melbourne, Melbourne, Vic; Founding Director, EJ Whitten Prostate Cancer Research Centre at Epworth Healthcare, Melbourne, Vic;@Head of Unit, Department of Urology, The Royal Melbourne Hospital, Melbourne, Vic.
Article Synopsis
- The increased use of imaging techniques has led to more frequent detection of incidental findings in the kidneys and adrenal glands, often referred to as incidentalomas, which are commonly encountered by general practitioners.* -
- This review provides guidelines for managing these renal and adrenal masses, highlighting that renal lesions are seen in about 14% of CT scans and should be assessed using the Bosniak classification for cystic lesions.* -
- For renal cell carcinomas larger than 4 cm or showing symptoms, active treatment is recommended, while adrenal lesions require functional testing, with specific screening tests indicated based on clinical signs such as hypertension.*
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