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Event-triggered adaptive compensation control for stochastic nonlinear systems with multiple failures: An improved switching threshold strategy.
ISA Trans
January 2025
School of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China; Qingdao Innovation Center of Artificial Intelligence Ocean Technology, Qingdao 266061, China; The Research Institute for Mathematics and Interdisciplinary Sciences, Qingdao University of Science and Technology, Qingdao 266061, China. Electronic address:
This paper considers the event-triggered adaptive fault-tolerant control (FTC) problem for a class of stochastic nonlinear systems suffering from finite number of actuator failures and abrupt system external failure. Unlike existing event-triggered mechanisms (ETMs), this paper proposes an improved switching threshold mechanism (STM) that effectively addresses the potential system security hazards caused by large signal impulses when both the magnitude size of the controller and its rate of change are too large, while also saving energy consumption. Especially, when the occurrence of both actuator failure and system external failure may lead to over-change rate of the controller, by using the multi-dimensional Taylor network (MTN) approximation technique, the adaptive fault-tolerant control scheme designed based on the improved STM not only has lower resource consumption, but also indirectly improves the control performance of the system by ensuring the system security operation.
View Article and Find Full Text PDFChallenges in estimating the counterfactual placebo HIV incidence rate from a registration cohort: The PrEPVacc trial.
Clin Trials
December 2024
Medical Research Council Clinical Trials Unit, University College London, London, UK.
Background: There is increasing recognition that the interpretation of active-controlled HIV prevention trials should consider the counterfactual placebo HIV incidence rate, that is, the rate that would have been observed if the trial had included a placebo control arm. The PrEPVacc HIV vaccine and pre-exposure prophylaxis trial (NCT04066881) incorporated a pre-trial registration cohort partly for this purpose. In this article, we describe our attempts to model the counterfactual placebo HIV incidence rate from the registration cohort.
View Article and Find Full Text PDFThe associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality - a prospective twin study.
Eur J Epidemiol
January 2025
Gerontology Research Center (GEREC), Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.
Objectives: The association between leisure-time physical activity (LTPA) and a lower risk of mortality is susceptible to bias from multiple sources. We investigated the potential of biological ageing to mediate the association between long-term LTPA and mortality and whether the methods used to account for reverse causality affect the interpretation of this association.
Methods: Study participants were twins from the older Finnish Twin Cohort (n = 22,750; 18-50 years at baseline).
A Cross-Biomeasure Study to Optimize Antiretroviral Adherence Estimation.
J Acquir Immune Defic Syndr
November 2024
University of North Carolina Eshelman School of Pharmacy, Chapel Hill, NC, USA.
Background: Incomplete adherence to daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) reduces effectiveness. Adherence biomeasures (i.e.
View Article and Find Full Text PDFIdentification of DNA methylation signatures in follicular-patterned thyroid tumors.
Pathol Res Pract
December 2024
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand; Precision Pathology of Neoplasia Research Group, Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. Electronic address:
Background And Aims: Follicular-patterned thyroid tumors (FPTTs) are frequently encountered in thyroid pathology, encompassing follicular adenoma (FA), follicular thyroid carcinoma (FTC), noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), and follicular variant of papillary thyroid carcinoma (fvPTC). Recently, a distinct entity termed differentiated high-grade thyroid carcinoma has been described by the 5th edition of the WHO classification of the thyroid tumors, categorized as either high-grade fvPTC, high-grade FTC or high-grade oncocytic carcinoma of the thyroid (OCA). Accurate differentiation among these lesions, particular between the benign (FA), borderline (NIFTP) and malignant neoplasms (FTC and fvPTC), remains a challenge in both histopathological and cytological diagnoses.
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