Acitretin (Ro 10-1670 or Neotigason), a free acid and the main metabolite of etretinate (Ro 10-9359 or Tigason), is the most recent of the retinoids used orally in the treatment of psoriasis and numerous other dermatoses exhibiting disorders of keratinization. In the majority of cases, its side-effects are similar to those of hypervitaminosis A.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1046/j.1365-2230.1998.00362.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases.
Mol Med
December 2024
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Article Synopsis
- - The study explores the potential of chlorquinaldol (CQ), an antimicrobial agent, as a specific inhibitor of the NLRP3 inflammasome, which is linked to various inflammatory diseases, highlighting its promise for drug repurposing.
- - CQ effectively suppresses NLRP3 inflammasome activation in both mouse and human macrophages primarily by blocking the interaction between NLRP3 and ASC, while having minimal impact on other inflammasomes like NLRC4 and AIM2.
- - In vivo tests showed that CQ significantly improves conditions in mouse models of LPS-induced peritonitis, DSS-induced colitis, and MSU-induced gouty arthritis, suggesting its therapeutic potential for treating NLRP3-related
Research hotspots and trends related to pain in gouty arthritis from 2014 to 2024: A bibliometric analysis.
Medicine (Baltimore)
November 2024
College of Integrative Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, China.
Background: Gouty arthritis is a metabolic condition caused by disordered purine metabolism and elevated uric acid levels. This study adopts a bibliometric approach to analyze current research on pain in gouty arthritis and forecast future research trends.
Methods: Retrieve relevant research on gouty arthritis pain in the Web of Science core collection database, screen literature, and use visualization software such as CiteSpace, Vosviewers, and R package "Bibliometrix" for analysis.
Sex dimorphism in kidney health and disease: mechanistic insights and clinical implication.
Kidney Int
January 2025
Department of Internal Medicine IV, Nephrology and Hypertension, Medical University Innsbruck, Innsbruck, Austria.
Sex is a key variable in the regulation of human physiology and pathology. Many diseases disproportionately affect one sex: autoimmune diseases, such as systemic lupus erythematosus, are more common in women but more severe in men, whereas the incidence of other disorders such as gouty arthritis and malignant cancers is higher in men. Besides the pathophysiology, sex may also influence the efficacy of therapeutics; participants in clinical trials are still predominately men, and the side effects of drugs are more common in women than in men.
View Article and Find Full Text PDFFrom Patents to Progress: Unraveling Gout's Journey Through Clinical Trials and Advancements.
Rev Recent Clin Trials
October 2024
Department of Pharmaceutics, Lovely Professional University, Phagwara, Punjab, 144001, India.
Article Synopsis
- Gout is an inflammatory arthritis linked to high levels of uric acid in the blood, leading to crystal formation and inflammation.
- The review highlights the rising prevalence of gout, its impact on public health, and various management strategies, including medications, dietary modifications, and lifestyle changes.
- Recent research explores innovative treatments like nanoparticles and new drugs, as well as advanced diagnostics for better detection and management of gout.
Spectrum of orbital fat necrosis in rhino-orbital-cerebral mucormycosis in post-COVID-19 patients.
Indian J Ophthalmol
October 2024
Department of Pathology, University College of Medical Sciences and GTB Hospital, Dilshad Garden, Delhi, India.
Article Synopsis
- Rhino-orbital-cerebral mucormycosis (ROCM) is a serious infection that often requires removal of the sinuses and eyeball to save patients, especially after the surge of cases following COVID-19 in India.
- A study involving 15 ROCM cases evaluated the presence and types of fat necrosis found during surgical removal, discovering significant findings like acute necrotizing fat necrosis and crystalline fat necrosis.
- Both CT scans and histopathological examinations confirmed fat necrosis as an important indicator of ROCM, with multiple patterns potentially present in a single case.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!