An expansion of CD8+ lymphocytes associated with a monoclonal rearrangement of the T-cell receptor gamma locus was found in a woman with HIV-1 infection. A subpopulation of HIV-positive patients display an unusual response to HIV infection characterized by a persistent marked CD8+ lymphocytosis, the presence of which appears to be associated with an improved long-term prognosis. This condition is thought to represent a florid immune response to an ongoing viral infection which may be HIV itself, and suggests that monoclonal proliferation of CD8+ lymphocytes does not imply the presence of an underlying malignant process.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
hiv infection
8
cd8+ lymphocytes
8
paraproteins monoclonal
4
monoclonal expansion
4
expansion cd3+cd8+
4
cd3+cd8+ cd56-cd57+
4
cd56-cd57+ lymphocytes
4
lymphocytes patient
4
patient hiv
4
infection
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!