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Two Patients with Therapy-Resistant Pemphigus Vulgaris and Severe Underlying Disease Showing Good Response to a New IVIg Preparation.
Dermatol Ther (Heidelb)
January 2025
Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
Pemphigus vulgaris is a severe and often therapy-resistant bullous autoimmune disease. Standard therapy with steroids often administered together with another immunosuppressant does not respond in all patients or may not be a good therapeutic option in patients with severe underlying diseases. Intravenous immunoglobulins (IVIgs) represent a treatment alternative, often showing a rapid response which allows one to reduce concomitant immunosuppression.
View Article and Find Full Text PDFResolution of Bullous Pemphigoid Following Lung Cancer Resection: A Case of Paraneoplastic Pemphigoid.
Cureus
November 2024
Department of Dermatology, JR Sapporo Hospital, Sapporo, JPN.
Bullous pemphigoid (BP) is a chronic autoimmune disorder characterized by subepidermal blister formation, primarily affecting elderly individuals. While BP has been associated with malignancies, the exact nature of this relationship remains unclear. We report the case of a 72-year-old man who presented with pruritic cutaneous lesions, including tense vesicles and bullae and was diagnosed with BP.
View Article and Find Full Text PDFUse of multivariant enzyme-linked immunosorbent assay (ELISA) in the diagnosis of autoimmune bullous disorders in a resource-limited setting: A single-center experience.
Indian J Dermatol Venereol Leprol
November 2024
Department of Dermatology, Venerology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- Autoimmune blistering disorders (AIBD) are conditions where the body produces auto-antibodies against adhesion proteins in the skin, detectable through direct immunofluorescence (DIF) or blood tests like ELISA.
- This study aimed to assess how well the results from a new multivariant ELISA method agreed with AIBD diagnoses established from clinical assessments, histopathology, and DIF.
- The results showed a good overall correlation between ELISA and diagnoses, particularly strong in pemphigus vulgaris, but with variable agreement levels in other types of AIBD and limitations due to the retrospective nature of the study.
[Autoimmune blistering dermatosis as a paraneoplastic syndrome secondary to testicular cancer].
Rev Med Inst Mex Seguro Soc
July 2024
Instituto Mexicano del Seguro Social, Hospital General de Zona No. 47, Servicio de Medicina Interna, Ciudad de México, México.
Background: In this case report, the connection between autoimmune bullous dermatosis acting as a paraneoplastic syndrome and testicular cancer is highlighted.
Clinical Case: A 28-year-old man with no chronic-degenerative diseases or medication consumption presented with erythematous macules and blisters on the chest, spreading to the back and limbs. Physical examination revealed eyelid erythema, conjunctival injection, ulcers on the tongue and lips, and blisters that denuded 90% of the body surface.
The use of ibrutinib for the management of paraneoplastic bullous pemphigoid associated with monoclonal B-lymphocytosis: A case report and brief literature review.
JAAD Case Rep
November 2024
Dermatology Department, Scripps Health, San Diego, California.
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