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Patients with autoimmune skin diseases are at increased risk of adverse pregnancy outcomes.
Am J Obstet Gynecol MFM
January 2024
Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, TX (Ms Keum, Drs Jacobe and Chong). Electronic address:
Background: Increased rates of adverse pregnancy outcomes have been reported in association with rheumatologic diseases such as systemic lupus erythematosus, rheumatoid arthritis, dermatomyositis. However, little is known about pregnancy outcomes in patients with autoimmune skin diseases.
Objective: This study aimed to determine the frequency of adverse pregnancy outcomes in patients with autoimmune skin diseases.
Linearity and Surface Anatomy of the Face: From Embryo to Senescence.
Curr Probl Dermatol
June 2023
Department of Dermatology, The Tattoo Clinic, Bispebjerg University Hospital, Copenhagen, Denmark.
Furrows, lines and wrinkles with distensibility and retractility are a biological need of skin in the service of skin integrity, plasticity and joint motion. The fundamental segmentation and linearity of skin is genetically coded, manifested early in embryonal life and remarkably constant throughout life. The basic pattern established early in embryonal life when facial segments expand and fuse is confounded by overlapping linearities of different backgrounds.
View Article and Find Full Text PDFMethotrexate in Linear Scleroderma: Long-Term Efficacy in Fifty Children From a Single Pediatric Rheumatology Center.
Arthritis Care Res (Hoboken)
September 2021
University of Padova, Padova, Italy.
Objective: To study disease course and long-term outcome in children with linear scleroderma (SSc) treated with methotrexate (MTX) since diagnosis.
Methods: The present study was retrospective and cross-sectional and included consecutive children with linear SSc who were treated with MTX for >1 year and were followed up for at least 2 years. Disease course was analyzed by the number of relapses and treatment changes.
Association of herpes zoster and chronic inflammatory skin disease in US inpatients.
J Am Acad Dermatol
December 2021
Department of Dermatology, The George Washington University School of Medicine and Health Sciences, Washington, DC. Electronic address:
Background: Patients with chronic inflammatory skin disease (CISD) have potential risk factors for herpes zoster (HZ). However, little is known about HZ risk in CISD.
Objective: To determine whether CISD is associated with HZ.
Early-Life Gut Dysbiosis: A Driver of Later-Life Fibrosis?
J Invest Dermatol
November 2017
Department of Medicine, Northwestern University, Chicago, Illinois, USA. Electronic address:
Using a novel mouse model of scleroderma induced by immunization with topoisomerase-I peptide-loaded dendritic cells, Mehta et al. found that early-life antibiotic exposure resulted in increased later-life fibrosis in the skin and lungs. These observations advance the novel concept that gut microbiome alterations caused by early-life exposures may contribute to scleroderma pathogenesis, and warrant in-depth characterization and validation in complementary disease models.
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