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Intestinal permeability, food antigens and the microbiome: a multifaceted perspective.
Front Allergy
January 2025
Department of Medicine and Surgery, Pediatric Unit, University of Perugia, Perugia, Italy.
The gut barrier encompasses several interactive, physical, and functional components, such as the gut microbiota, the mucus layer, the epithelial layer and the gut mucosal immunity. All these contribute to homeostasis in a well-regulated manner. Nevertheless, this frail balance might be disrupted for instance by westernized dietary habits, infections, pollution or exposure to antibiotics, thus diminishing protective immunity and leading to the onset of chronic diseases.
View Article and Find Full Text PDFDetermination of the Zebrafish Embryo Developmental Toxicity Assessment (ZEDTA) as an Alternative Non-Mammalian Approach for the Safety Assessment of Agrochemicals.
Reprod Toxicol
January 2025
Biosciences, Faculty of Health and Life Sciences, University of Exeter, Stocker Road, Exeter, Devon, EX4 4QD, UK. Electronic address:
With the US Environment Protection Agency reducing requests for (and funding of) mammalian studies alongside the proposed elimination of requests by 2035, there is an urgent need for fully validated New Approach Methods (NAMs) to fill the resultant gap for safety assessment of agrochemicals. One promising NAM for assessing the potential for human prenatal developmental toxicity potential is the Zebrafish Embryo Developmental Toxicity Assessment, a bioassay that has been used by the pharmaceutical industry for more than a decade in early-stage drug safety assessment. Despite its promise, little data has been generated to assess the validity of ZEDTA for assessing Developmental and Reproductive Toxicity of new agrochemical products.
View Article and Find Full Text PDFNationwide representative serosurvey of third-grade school children to evaluate the hepatitis B vaccination impact in Kyrgyzstan, 2022.
BMC Infect Dis
January 2025
WHO Regional Office for Europe, Marmorvej 51, Copenhagen, 2100, Denmark.
Background: Kyrgyzstan introduced universal hepatitis B childhood vaccination in 1999 to reduce the burden of hepatitis B. In 2016, aligned with the goal of controlling hepatitis B in the WHO European Region, a regional target of 0.5% was set for seroprevalence of hepatitis B surface antigen (HBsAg) among targeted birth cohorts.
View Article and Find Full Text PDFExploring the immune resilience of Mediterranean mussels: Recent advances and future directions.
Fish Shellfish Immunol
January 2025
University of Trieste, Department of Life Sciences, Italy.
The Mediterranean mussel (Mytilus galloprovincialis) is a key species in European aquaculture, known for its economic and societal importance, particularly as a primary source of income for local fisheries in European coastal areas. While historically resilient to the mass mortality events that have affected other bivalve species, M. galloprovincialis may face increasing threats from emerging pathogens, including bacteria, viruses, and eukaryotic parasites.
View Article and Find Full Text PDFA single droplet dispensing system for high-throughput screening and reliable recovery of rare events.
Lab Chip
January 2025
VERAXA Biotech GmbH, 69124 Heidelberg, Germany.
Microfluidic droplet sorting has emerged as a powerful technique for a broad spectrum of biomedical applications ranging from single cell analysis to high-throughput drug screening, biomarker detection and tissue engineering. However, the controlled and reliable retrieval of selected droplets for further off-chip analysis and processing is a significant challenge in droplet sorting, particularly in high-throughput applications with low expected hit rates. In this study, we present a microfluidic platform capable of sorting and dispensing individual droplets with minimal loss rates.
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