AI Article Synopsis
Article Abstract
Ninjurin is a protein that is up-regulated in Schwann cells and neurons after peripheral nerve injury. Its role in promoting nerve regeneration and its expression in sensory neurons of dorsal root ganglia, as well as the chromosomal localization of the ninjurin gene, makes this gene a candidate for hereditary sensory neuropathies (HSN). In the present report, the human ninjurin gene was analyzed in 17 unrelated patients with HSN type I, two patients with HSN type II, and 10 normal controls, by single strand conformation polymorphism and by direct sequencing. All three exons and splice junctions of the gene were investigated and no mutations were found in our sample of patients. Our results rule out a mutation in the translated region of the ninjurin gene as a cause of HSN type I and type II.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Abrupt-mediated control of ninjurins regulates Drosophila sessile haemocyte compartments.
Development
December 2024
Institute of Cancer and Genomic Sciences, University of Birmingham, Edgbaston B15 2TT, UK.
Article Synopsis
- Hemocytes, macrophage-like cells in Drosophila, play a crucial role in the immune response and can be found either circulating or in stationary groups known as sessile hemocyte compartments (SHCs).
- The study identifies the transcription factor Abrupt and Ninjurin cell adhesion molecules as key regulators for the recruitment of hemocytes to SHCs, particularly during the developmental stage of pupariation.
- Manipulations affecting Ninjurin function reveal that it is essential for hemocyte targeting to SHCs; disrupting this function leads to premature dispersal of hemocytes, highlighting the importance of Ninjurin in mediating immune responses and managing hemocyte distribution during development.
Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture.
Nature
January 2025
Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Lytic cell death culminates in plasma membrane rupture, which releases large intracellular molecules to augment the inflammatory response. Plasma membrane rupture is mediated by the effector membrane protein ninjurin-1 (NINJ1), which polymerizes and ruptures the membrane via its hydrophilic face. How NINJ1 is restrained under steady-state conditions to ensure cell survival remains unknown.
View Article and Find Full Text PDFEffects of polymorphisms on susceptibility to coronary heart disease.
Cell Cycle
February 2024
Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Objective: The aim of this study was to explore the effects of Ninjurin 2 (NINJ2) polymorphisms on susceptibility to coronary heart disease (CHD).
Methods: We conducted a case-control study with 499 CHD cases and 505 age and gender-matched controls. Five single nucleotide polymorphisms (SNPs) in NINJ2 (rs118050317, rs75750647, rs7307242, rs10849390, and rs11610368) were genotyped by the Agena MassARRAY platform.
Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells.
Int J Mol Sci
January 2024
Departments of Parasitology and Genetics, Kosin University College of Medicine, Busan 49241, Republic of Korea.
Tight junction (TJ) proteins (Tjps), Tjp1 and Tjp2, are tight junction-associated scaffold proteins that bind to the transmembrane proteins of tight junctions and the underlying cytoskeleton. In this study, we first analyzed the tumorigenic characteristics of B16-F10 melanoma cells, including cell proliferation, migration, invasion, metastatic potential, and the expression patterns of related proteins, after the CRISPR-Cas9-mediated knockout (KO) of genes. The proliferation of and KO cells significantly increased in vitro.
View Article and Find Full Text PDFRedox regulation of the NLRP3-mediated inflammation and pyroptosis.
Biomed Khim
December 2023
V.I. Razumovsky Saratov State Medical University, Saratov, Russia.
The review considers modern data on the mechanisms of activation and redox regulation of the NLRP3 inflammasome and gasdermins, as well as the role of selenium in these processes. Activation of the inflammasome and pyroptosis represent an evolutionarily conserved mechanism of the defense against pathogens, described for various types of cells and tissues (macrophages and monocytes, microglial cells and astrocytes, podocytes and parenchymal cells of the kidneys, periodontal tissues, osteoclasts and osteoblasts, as well as cells of the digestive and urogenital systems, etc.).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!