AI Article Synopsis
- The thymus is critical for the development of mature T cells, as it is colonized by progenitor cells influenced by its unique microenvironment.
- Recent research identifies ChT1, an antigen in the Ig superfamily, as a significant player in T cell development, particularly among early T cell progenitors.
- ChT1-specific antibodies can inhibit the differentiation of T cells in laboratory models, underscoring its role in early T cell maturation.
Article Abstract
The thymus is colonized by circulating progenitor cells that differentiate into mature T cells under the influence of the thymic microenvironment. We report here the cloning and function of the avian thymocyte Ag ChT1, a member of the Ig superfamily with one V-like and one C2-like domain. ChT1-positive embryonic bone marrow cells coexpressing c-kit give rise to mature T cells upon intrathymic cell transfer. ChT1-specific Ab inhibits T cell differentiation in embryonic thymic organ cultures and in thymocyte precursor cocultures on stromal cells. Thus, we provide clear evidence that ChT1 is a novel Ag on early T cell progenitors that plays an important role in the early stages of T cell development.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!