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Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling.
Neuroscience
June 2010
Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA.
Aspirin, whose active ingredient is sodium salicylate, is the most widely used drug worldwide, but it is not recommended for children because it may cause Reye's syndrome. High doses of salicylate also induce temporary hearing loss and tinnitus; while these disorders are believed to disappear when treatment is discontinued some data suggest that prolonged treatment may be neurotoxic. To investigate its ototoxicity, immature, postnatal day 3 rat cochlear organotypic cultures were treated with salicylate.
View Article and Find Full Text PDF[Influenza encephalopathy, related disorders and differential diagnosis].
Nihon Rinsho
November 2003
Office of Medical Education, Kurume University School of Medicine.
Influenza encephalopathy and related disorders such as Reye's syndrome, acute necrotizing encephalopathy and acute hemorrhagic encephalopathy are still undefined clinical entities because the pathophysiology is not clearly established. Even Reye's syndrome which has been extensively studied during the last two decades, its real picture has not been well established. Moreover, Reye's syndrome is going to disappear just like Ekiri syndrome.
View Article and Find Full Text PDFReye's syndrome in a 17-year-old male: is this disease really disappearing?
Dig Dis Sci
September 2002
Center for the Study of Liver Diseases, University of Miami School of Medicine, Florida 33136, USA.
Is aspirin a cause of Reye's syndrome? A case against.
Drug Saf
September 2002
Pediatric Intensive Care Unit, University Community Hospital, Tampa, Florida 33613, USA.
Article Synopsis
- * No evidence has been found of salicylates in the blood or urine of affected patients, and no animal models show that aspirin can trigger the disease.
- * The decline in Reye's syndrome cases began prior to any warnings about aspirin, suggesting it might have been a viral mutation or a collection of metabolic disorders misidentified at the time.
Salicylates, nitric oxide, malaria, and Reye's syndrome.
Lancet
February 2001
Division of Biochemistry & Molecular Biology, School of Life Sciences, Australian National University, Canberra, Australian Capital Territory.
Reye's syndrome virtually disappeared from much of the world after the use of salicylate in febrile children was successfully discouraged. This severe sepsis-like disease was thought to be caused by a hypersensitivity to salicylates in children with mild viral infections, although no mechanism consistent with this proposal was ever established. Salicylate toxicity in African children has been noted to have many clinical features in common with severe falciparum malaria, including acidosis, altered consciousness, convulsions, and hypoglycaemia.
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