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Photodynamic inactivation mediated by natural alizarin on bacteria for the safety of fresh-cut apples.
Food Res Int
January 2025
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:
Most photosensitizers have limited responsiveness to visible light, however, visible light is a light source with a wide range of wavelengths and the most common in daily life, and making full use of visible light can help to enhance the photodynamic antimicrobial properties of photosensitizers. To tackle this issue, this study confirmed that alizarin has a good absorption capacity for visible light by UV-DRS analysis. Theoretical calculations showed that alizarin might be excited through the charge transfer (CT) mechanism.
View Article and Find Full Text PDFStable Antifouling and Antibacterial Coating Based on Assembly of Copper-Phenolic Networks.
ACS Appl Bio Mater
January 2025
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta T6G 1H9, Canada.
Biofilm formation on medical devices has become a worldwide issue arising from its resistance to bactericidal agents and presenting challenges to eradicating biofouling adhesion, especially in biological fluids. Metal-phenolic networks have been demonstrated as a versatile and efficient strategy to prevent biofilm formation by endowing medical devices with prolonged antifouling and antibacterial activities in a one-step surface modification. In this study, we report a simple and environmentally friendly method using coordination chemistry between copper ions (Cu) and dopamine-containing copolymer to fabricate metal-phenolic network-based coatings.
View Article and Find Full Text PDFGraveyard effects of antimicrobial nanostructured titanium over prolonged exposure to drug resistant bacteria and fungi.
Nanoscale
December 2024
School of Science, College of STEM, RMIT University, Melbourne, Victoria 3000, Australia.
Innovations in nanostructured surfaces have found a practical place in the medical area with use in implant materials for post-operative infection prevention. These textured surfaces should be dual purpose: (1) bactericidal on contact and (2) resistant to biofilm formation over prolonged periods. Here, hydrothermally etched titanium surfaces were tested against two highly antimicrobial resistant microbial species, methicillin-resistant and .
View Article and Find Full Text PDFRegimen comprising clarithromycin, clofazimine and bedaquiline is more efficacious than monotherapy in a mouse model of chronic lung infection.
bioRxiv
December 2024
Division of Infectious Diseases, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
, a leading non-tuberculous mycobacterium (NTM) pathogen, causes chronic pulmonary infections, particularly in individuals with underlying lung conditions or immunosuppression. Current treatments involve prolonged multi-drug regimens with poor outcomes and significant side effects, highlighting the urgent need for improved therapies. Using a BALB/c mouse model of chronic pulmonary disease, we evaluated the efficacy of individual antibiotics-clarithromycin, clofazimine, and rifabutin-and combination regimens including clarithromycin+bedaquiline and clarithromycin+clofazimine+bedaquiline.
View Article and Find Full Text PDFRational design and synthesis of novel phenyltriazole derivatives targeting MRSA cell wall biosynthesis.
RSC Adv
December 2024
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University Nasr City 11884 Cairo Egypt
Antimicrobial resistance in methicillin-resistant (MRSA) is a major global health challenge. This study reports the design and synthesis of novel phenyltriazole derivatives as potential anti-MRSA agents. The new scaffold replaces the thiazole core with a 1,2,3-triazole ring, enhancing antimicrobial efficacy and physicochemical properties.
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