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Acupuncture: An Overview on Its Functions, Meridian Pathways and Molecular Mechanisms.
Am J Chin Med
September 2024
Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, P. R. China.
Recent research has extensively explored the intricate mechanisms that underlie the effectiveness of acupuncture, highlighting the importance of stimulating acupoints, the role of acupuncture techniques in managing diseases, and the interaction between meridian pathways and molecular processes. Studies have underscored the crucial role of acupuncture in activating neurons, modulating the immune system, and influencing vascular activity, all of which contribute significantly to its therapeutic benefits across a wide range of symptoms and conditions. Utilization of imaging modalities enables the identification of changes in cerebral blood flow, brain function, and regional glucose metabolism following acupuncture sessions.
View Article and Find Full Text PDFIdentification of a serum proteomic biomarker panel using diagnosis specific ensemble learning and symptoms for early pancreatic cancer detection.
PLoS Comput Biol
August 2024
Institute for Liver and Digestive Health, University College London, London, United Kingdom.
Background: The grim (<10% 5-year) survival rates for pancreatic ductal adenocarcinoma (PDAC) are attributed to its complex intrinsic biology and most often late-stage detection. The overlap of symptoms with benign gastrointestinal conditions in early stage further complicates timely detection. The suboptimal diagnostic performance of carbohydrate antigen (CA) 19-9 and elevation in benign hyperbilirubinaemia undermine its reliability, leaving a notable absence of accurate diagnostic biomarkers.
View Article and Find Full Text PDFDevelopment of a Structured Query Language and Natural Language Processing Algorithm to Identify Lung Nodules in a Cancer Centre.
Front Med (Lausanne)
November 2021
The Royal Marsden National Health Service (NHS) Foundation Trust, Lung Unit, London, United Kingdom.
The stratification of indeterminate lung nodules is a growing problem, but the burden of lung nodules on healthcare services is not well-described. Manual service evaluation and research cohort curation can be time-consuming and potentially improved by automation. To automate lung nodule identification in a tertiary cancer centre.
View Article and Find Full Text PDFMicroRNAs Involved in Small-cell Lung Cancer as Possible Agents for Treatment and Identification of New Targets.
Cancer Genomics Proteomics
January 2022
Roche Pharma Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany
Small-cell lung cancer, a neuro-endocrine type of lung cancers, responds very well to chemotherapy-based agents. However, a high frequency of relapse due to adaptive resistance is observed. Immunotherapy-based treatments with checkpoint inhibitors has resulted in improvement of treatment but the responses are not as impressive as in other types of tumor.
View Article and Find Full Text PDFExploring neuropeptide signalling through proteomics and peptidomics.
Expert Rev Proteomics
February 2019
a Animal Physiology and Neurobiology, Department of Biology , KU Leuven , Leuven , Belgium.
Neuropeptides are neuro-endocrine signaling molecules capable of signaling as neurotransmitters, neuromodulators or neurohormones. Studying how neuropeptide signaling is integrated in endocrine pathways and how neuropeptides regulate endogenous processes is crucial to understanding how multicellular organisms respond to environmental and internal cues. Areas covered: This review will cover proteomics and peptidomics approaches used in researching peptide signaling systems and breakthroughs that were achieved in this field.
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