We introduce a recurrent network architecture for modelling a general class of dynamical systems. The network is intended for modelling real-world processes in which empirical measurements of the external and state variables are obtained at discrete time points. The model can learn from multiple temporal patterns, which may evolve on different timescales and be sampled at non-uniform time intervals. We demonstrate the application of the model to a synthetic problem in which target data are only provided at the final time step. Despite the sparseness of the training data, the network is able not only to make good predictions at the final time step for temporal processes unseen in training, but also to reproduce the sequence of the state variables at earlier times. Moreover, we show how the network can infer the existence and role of state variables for which no target information is provided. The ability of the model to cope with sparse data is likely to be useful in a number of applications, including, in particular, the modelling of metal forging.
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Adv Clin Chem
January 2025
Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, United States. Electronic address:
Gaucher disease (GD) is a rare lysosomal disorder characterized by the accumulation of glycosphingolipids in macrophages resulting from glucocerebrosidase (GCase) deficiency. The accumulation of toxic substrates, which causes the hallmark symptoms of GD, is dependent on the extent of enzyme dysfunction. Accordingly, three distinct subtypes have been recognized, with type 1 GD (GD1) as the common and milder form, while types 2 (GD2) and 3 (GD3) are categorized as neuronopathic and severe.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Department of Agricultural and Environmental Biotechnology, São Paulo State University (UNESP), School of Agricultural and Veterinarian Sciences, Jaboticabal, São Paulo, Brazil; Institute of Bioenergy Research (IPBEN), Jaboticabal, São Paulo, Brazil. Electronic address:
This study characterized a novel bacterial lipase with high biotechnological potential, focusing on industrial and environmental applications. Bacterial isolates were screened using olive oil as a substrate, and the strain with the highest hydrolytic halo was identified as Burkholderia sp. via 16S rRNA analysis.
View Article and Find Full Text PDFPhysiol Behav
January 2025
Department of Pedagogy, Psychology, Philosophy, University of Cagliari, Via Is Mirrionis 1, 09123 Cagliari, Italy.
This study was mainly aimed at exploring the effect of gender on the patterns of Physical Activty (PA) in older people living in an area of exceptional longevity, the so-called Sardinian Blue Zone. Furthermore, the study intended to investigate the nature of the relationships among PA metrics, cognitive measures, and age. One hundred and nine community-dwelling participants (M = 81.
View Article and Find Full Text PDFObjectives: To characterize the 1) types of material goods (non-medical items) offered in pediatric residency continuity clinics, 2) consistency of good availability, 3) funding sources used to support supply, 4) whether goods are provided in response to social needs screening, and 5) common challenges with provision. To assess the extent to which provision of goods varied by clinic size and proportion of publicly insured patients.
Methods: Faculty and staff members from clinics in the Academic Pediatric Association's Continuity Research Network (APA CORNET) completed an online survey about material goods provided in their clinic in the preceding 12 months.
Sci Total Environ
January 2025
Department of Chemistry, Physics, Environmental and Soil Sciences, University of Lleida - AGROTECNIO-CERCA Center, Rovira Roure 191, 25198 Lleida, Spain.
There is limited research on the influence of environmental variables on the interactions of biodegradable microplastics with chromium. This study reports the results of adsorption experiments with Cr and poly(lactic acid) (PLA) in synthetic aqueous solutions. It addresses the influence of the initial oxidation state, Cr(III) or Cr(VI), the effects of UV irradiation and the presence of organic matter.
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