AI Article Synopsis
- A cDNA clone for angiopoietin-3 (Ang3), a new member of the angiopoietin family, was discovered from a human aorta cDNA library.
- Ang3 is composed of 503 amino acids and shows about 45% similarity to angiopoietin-1 and 44.7% to angiopoietin-2.
- Ang3 mRNA is found in lung tissue and cultured human umbilical vein endothelial cells (HUVECs), with its expression slightly decreased by vascular endothelial cell growth factor treatment, indicating different regulatory mechanisms compared to angiopoietin-2.
Article Abstract
A cDNA clone encoding angiopoietin-3 protein (Ang3), a novel member of the angiopoietin family, was identified. Ang3 cDNA was cloned from a human aorta cDNA library. Ang3 is a 503 amino acid protein having 45.1% and 44.7% identity with human angiopoietin-1 and human angiopoietin-2, respectively. Ang3 mRNA is expressed in lung and cultured human umbilical vein endothelial cells (HUVECs). Ang3 mRNA expression in HUVECs was slightly decreased by vascular endothelial cell growth factor treatment, suggesting that the regulation of Ang3 mRNA expression is different from that of Ang2.
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| http://dx.doi.org/10.1016/s0014-5793(99)00381-6 | DOI Listing |
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